C-type lectin domain family 17, member A

UniProt data

UniProt name: CL17A_HUMAN (Q6ZS10)

Gene name: CLEC17A

Organism: Homo sapiens (Human).

Function: Cell surface receptor which may be involved in carbohydrate-mediated communication between cells in the germinal center. Binds glycans with terminal alpha-linked mannose or fucose residues. {ECO:0000269|PubMed:19419970}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}. Note=In fibroblasts, expressed on the cell surface. {ECO:0000269|PubMed:19419970}.

Transmembrane domains:

  1. 173-193, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 378 AA

10 20 30 40 50 60 MHNLYSITGY PDPPGTMEEE EEDDDYENST PPYKDLPPKP GTMEEEEEDD DYENSTPPYK 70 80 90 100 110 120 DLPPKPGTME EEEEDDDYEN STPPYKDLPP KPGSSAPPRP PRAAKETEKP PLPCKPRNMT 130 140 150 160 170 180 GLDLAAVTCP PPQLAVNLEP SPLQPSLAAT PVPWLNQRSG GPGCCQKRWM VYLCLLVVTS 190 200 210 220 230 240 LFLGCLGLTV TLIKYQELME ELRMLSFQQM TWRTNMTGMA GLAGLKHDIA RVRADTNQSL 250 260 270 280 290 300 VELWGLLDCR RITCPEGWLP FEGKCYYFSP STKSWDEARM FCQENYSHLV IINSFAEHNF 310 320 330 340 350 360 VAKAHGSPRV YWLGLNDRAQ EGDWRWLDGS PVTLSFWEPE EPNNIHDEDC ATMNKGGTWN 370 DLSCYKTTYW ICERKCSC

CATM prediction

The sequence of CL17A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  170       180       190    
|    +    |    +    |    + 		 (Å) (°) (Å) (°)  
Model 1 MVYLCLLVVTSLFLGCLGLTVTLIKYQ 7.3 -55.0° 2.4 47.6 -0.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 187, GLY, HA1 A, 184, GLY, O 3.33Å
B, 188, LEU, HA A, 191, THR, OG1 2.71Å
A, 187, GLY, HA1 B, 184, GLY, O 3.33Å
A, 188, LEU, HA B, 191, THR, OG1 2.71Å