Cation channel sperm-associated protein subunit gamma

UniProt data

UniProt name: CTSRG_HUMAN (Q6ZRH7)

Gene name: CATSPERG; Synonyms=C19orf15

Organism: Homo sapiens (Human).

Function: Probably involved in sperm cell hyperactivation via its association with CATSPER1. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1067-1087, 21 AA, Helical. {ECO:0000255}.

Sequence: 1159 AA

10 20 30 40 50 60 MCGPAMFPAG PPWPRVRVVQ VLWALLAVLL ASWRLWAIKD FQECTWQVVL NEFKRVGESG 70 80 90 100 110 120 VSDSFFEQEP VDTVSSLFHM LVDSPIDPSE KYLGFPYYLK INYSCEEKPS EDLVRMGHLT 130 140 150 160 170 180 GLKPLVLVTF QSPVNFYRWK IEQLQIQMEA APFRSKEPCM AEEVCSMSWY TPMPIKKGSV 190 200 210 220 230 240 VMRVDISSNG LGTFIPDKRF QMNINGFLKR DRDNNIQFTV GEELFNLMPQ YFVGVSSRPL 250 260 270 280 290 300 WHTVDQSPVL ILGGIPNEKY VLMTDTSFKD FSLVELSIDS CWVGSFYCPH SGFTATIYDT 310 320 330 340 350 360 IATESTLFIR QNQLVYYFTG TYTTLYERNR GSGSWIRVLA SECIKKLCPV YFHSNGSEYI 370 380 390 400 410 420 MALTTGKHEG YVHFGTIRDG QVSFEMLPRQ WSVCEQIGVT TCSIIWSEYI AGEYTLLLLV 430 440 450 460 470 480 ESGYGNASKR FQVVSYNTAS DDLELLYHIP EFIPEARGLE FLMILGTESY TSTAMAPKGI 490 500 510 520 530 540 FCNPYNNLIF IWGNFLLQSS NKENFIYLAD FPKELSIKYM ARSFRGAVAI VTETEEIWYL 550 560 570 580 590 600 LEGSYRVYQL FPSKGWQVHI SLKLMQQSSL YASNETMLTL FYEDSKLYQL VYLMNNQKGQ 610 620 630 640 650 660 LVKRLVPVEQ LLMYQQHTSH YDLERKGGYL MLSFIDFCPF SVMRLRSLPS PQRYTRQERY 670 680 690 700 710 720 RARPPRVLER SGFHNENSLA IYQGLVYYLL WLHSVYDKPY ADPVHDPTWR WWANNKQDQD 730 740 750 760 770 780 YYFFLASNWR SAGGVSIEMD SYEKIYNLES AYELPERIFL DKGTEYSFAI FLSAQGHSFR 790 800 810 820 830 840 TQSELGTAFQ LHSQVDVGVV LADPGCIEAS VKQEVLINRN SVLFSITLKD KKLCYDQGIS 850 860 870 880 890 900 GHHLMETSMT VNVVGSSGLC FQETHLGPHM QGNLMVPVFI GCPPGKRLAF DITYTLEYSR 910 920 930 940 950 960 LKNKHYFDCV NVNPEMPCFL FRDIFYPFFL IQDLVTGDSG SFQGSYVLLV VGGGPTLDSL 970 980 990 1000 1010 1020 KDYSEDEIYR FNSPLDKTNS LIWTTRTTRT TKDSAFHIMS HESPGIEWLC LENAPCYDNV 1030 1040 1050 1060 1070 1080 PQGIFAPEFF FKVLVSNRGV DTSTYCNYQL TFLLHIHGLP LSPKRALFII MVSASVFVGL 1090 1100 1110 1120 1130 1140 VIFYIAFCLL WPLVVKGCTM IRWKINNLIA SESYYTYASI SGISSMPSLR HSRMGSMFSS 1150 RMTEDRAEPK EAVERQLMT

CATM prediction

The sequence of CTSRG_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        1070      1080      1
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 KRALFIIMVSASVFVGLVIFYIAFCLL 7.3 -54.1° 3.6 49.2 -10.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1072, VAL, HA A, 1075, SER, OG 3.02Å
B, 1076, VAL, HA A, 1075, SER, O 3.20Å
B, 1079, GLY, HA1 A, 1076, VAL, O 3.36Å
A, 1072, VAL, HA B, 1075, SER, OG 3.02Å
A, 1076, VAL, HA B, 1075, SER, O 3.20Å
A, 1079, GLY, HA1 B, 1076, VAL, O 3.36Å