Transmembrane protease serine 11A

UniProt data

UniProt name: TM11A_HUMAN (Q6ZMR5)

Gene name: TMPRSS11A; Synonyms=ECRG1, HATL1, HESP

Organism: Homo sapiens (Human).

Function: Probable serine protease which may play a role in cellular senescence. Overexpression inhibits cell growth and induce G1 cell cycle arrest.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 19-39, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 421 AA

10 20 30 40 50 60 MMYRTVGFGT RSRNLKPWMI AVLIVLSLTV VAVTIGLLVH FLVFDQKKEY YHGSFKILDP 70 80 90 100 110 120 QINNNFGQSN TYQLKDLRET TENLVSQVDE IFIDSAWKKN YIKNQVVRLT PEEDGVKVDV 130 140 150 160 170 180 IMVFQFPSTE QRAVREKKIQ SILNQKIRNL RALPINASSV QVNAMSSSTG ELTVQASCGK 190 200 210 220 230 240 RVVPLNVNRI ASGVIAPKAA WPWQASLQYD NIHQCGATLI SNTWLVTAAH CFQKYKNPHQ 250 260 270 280 290 300 WTVSFGTKIN PPLMKRNVRR FIIHEKYRSA AREYDIAVVQ VSSRVTFSDD IRRICLPEAS 310 320 330 340 350 360 ASFQPNLTVH ITGFGALYYG GESQNDLREA RVKIISDDVC KQPQVYGNDI KPGMFCAGYM 370 380 390 400 410 420 EGIYDACRGD SGGPLVTRDL KDTWYLIGIV SWGDNCGQKD KPGVYTQVTY YRNWIASKTG I

CATM prediction

The sequence of TM11A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      20        30        40 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 KAWMIAVLIVLSLTVVAVTIGLLVHFL 7.3 -50.8° 3.3 48.4 -20.7
Prolines* KPWMIAVLIVLSLTVVAVTIGLLVHFL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 33, VAL, HA A, 32, ALA, O 3.17Å
B, 36, GLY, HA1 A, 33, VAL, O 3.27Å
A, 33, VAL, HA B, 32, ALA, O 3.17Å
A, 36, GLY, HA1 B, 33, VAL, O 3.27Å