Gliomedin

UniProt data

UniProt name: GLDN_HUMAN (Q6ZMI3)

Gene name: GLDN; Synonyms=COLM; ORFNames=UNQ9339/PRO34011

Organism: Homo sapiens (Human).

Function: Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC. Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters. Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier. {ECO:0000250|UniProtKB:Q8BMF8}.

Subcellular location: Gliomedin shedded ectodomain: Secreted {ECO:0000250|UniProtKB:Q80WL1}. Secreted, extracellular space, extracellular matrix {ECO:0000250|UniProtKB:Q80WL1}. Note=Proteolytic processing gives rise to a soluble extracellular domain that is secreted. The gliomedin shedded ectodomain localizes to the nodes of Ranvier. {ECO:0000250|UniProtKB:Q80WL1}.

Transmembrane domains:

  1. 18-39, 22 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 551 AA

10 20 30 40 50 60 MARGAEGGRG DAGWGLRGAL AAVALLSALN AAGTVFALCQ WRGLSSALRA LEAQRGREQR 70 80 90 100 110 120 EDSALRSFLA ELSRAPRGAS APPQDPASSA RNKRSHSGEP APHIRAESHD MLMMMTYSMV 130 140 150 160 170 180 PIRVMVDLCN STKGICLTGP SGPPGPPGAG GLPGHNGLDG QPGPQGPKGE KGANGKRGKM 190 200 210 220 230 240 GIPGAAGNPG ERGEKGDHGE LGLQGNEGPP GQKGEKGDKG DVSNDVLLAG AKGDQGPPGP 250 260 270 280 290 300 PGPPGPPGPP GPPGSRRAKG PRQPSMFNGQ CPGETCAIPN DDTLVGKADE KASEHHSPQA 310 320 330 340 350 360 ESMITSIGNP VQVLKVTETF GTWIRESANK SDDRIWVTEH FSGIMVKEFK DQPSLLNGSY 370 380 390 400 410 420 TFIHLPYYFH GCGHVVYNNS LYYHKGGSNT LVRFEFGQET SQTLKLENAL YFDRKYLFAN 430 440 450 460 470 480 SKTYFNLAVD EKGLWIIYAS SVDGSSILVA QLDERTFSVV QHVNTTYPKS KAGNAFIARG 490 500 510 520 530 540 ILYVTDTKDM RVTFAFDLLG GKQINANFDL RTSQSVLAML AYNMRDQHLY SWEDGHLMLY 550 PVQFLSTTLN Q

CATM prediction

The sequence of GLDN_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       20        30        40 
+    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 GLRGALAAVALLSALNAAGTVFALCQWR 7.1 -55.1° 0.9 49.9 -15.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 33, GLY, HA1 A, 30, ASN, O 3.20Å
B, 34, THR, HA A, 33, GLY, O 3.45Å
A, 33, GLY, HA1 B, 30, ASN, O 3.20Å
A, 34, THR, HA B, 33, GLY, O 3.45Å