UniProt data
UniProt name: SIG15_HUMAN (Q6ZMC9)
Gene name: SIGLEC15; Synonyms=CD33L3
Organism: Homo sapiens (Human).
Function: Binds sialylated glycoproteins. {ECO:0000269|PubMed:17483134}.
Subcellular location: Membrane; Single-pass type I membrane protein.
Transmembrane domains:
- 264-284, 21 AA, Helical. {ECO:0000255}.
Sequence: 328 AA
10 20 30 40 50 60
MEKSIWLLAC LAWVLPTGSF VRTKIDTTEN LLNTEVHSSP AQRWSMQVPP EVSAEAGDAA
70 80 90 100 110 120
VLPCTFTHPH RHYDGPLTAI WRAGEPYAGP QVFRCAAARG SELCQTALSL HGRFRLLGNP
130 140 150 160 170 180
RRNDLSLRVE RLALADDRRY FCRVEFAGDV HDRYESRHGV RLHVTAAPRI VNISVLPSPA
190 200 210 220 230 240
HAFRALCTAE GEPPPALAWS GPALGNSLAA VRSPREGHGH LVTAELPALT HDGRYTCTAA
250 260 270 280 290 300
NSLGRSEASV YLFRFHGASG ASTVALLLGA LGFKALLLLG VLAARAARRR PEHLDTPDTP
310 320
PRSQAQESNY ENLSQMNPRS PPATMCSP
CATM prediction
The sequence of SIG15_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 270 280 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | ASTVALLLGALGFKALLLLGVLAARAA | 7.4 | -48.0° | 0.5 | 47.0 | -16.1 |
| Model 2 | ASTVALLLGALGFKALLLLGVLAARAA | 6.8 | -55.0° | 2.4 | 47.9 | -13.6 |
| Model 3 | ASTVALLLGALGFKALLLLGVLAARAA | 7.1 | +51.7° | 1.8 | 1.0 | -0.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 280, GLY, HA1 | A, 277, LEU, O | 3.44Å |
| B, 281, VAL, HA | A, 280, GLY, O | 3.40Å |
| A, 280, GLY, HA1 | B, 277, LEU, O | 3.44Å |
| A, 281, VAL, HA | B, 280, GLY, O | 3.40Å |
