Cytochrome P450 26C1

UniProt data

UniProt name: CP26C_HUMAN (Q6V0L0)

Gene name: CYP26C1

Organism: Homo sapiens (Human).

Function: Plays a role in retinoic acid metabolism. Acts on retinoids, including all-trans-retinoic acid (RA) and its stereoisomer 9-cis-RA (preferred substrate).

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 9-29, 21 AA, Helical. {ECO:0000255}.

Sequence: 522 AA

10 20 30 40 50 60 MFPWGLSCLS VLGAAGTALL CAGLLLSLAQ HLWTLRWMLS RDRASTLPLP KGSMGWPFFG 70 80 90 100 110 120 ETLHWLVQGS RFHSSRRERY GTVFKTHLLG RPVIRVSGAE NVRTILLGEH RLVRSQWPQS 130 140 150 160 170 180 AHILLGSHTL LGAVGEPHRR RRKVLARVFS RAALERYVPR LQGALRHEVR SWCAAGGPVS 190 200 210 220 230 240 VYDASKALTF RMAARILLGL RLDEAQCATL ARTFEQLVEN LFSLPLDVPF SGLRKGIRAR 250 260 270 280 290 300 DQLHRHLEGA ISEKLHEDKA AEPGDALDLI IHSARELGHE PSMQELKESA VELLFAAFFT 310 320 330 340 350 360 TASASTSLVL LLLQHPAAIA KIREELVAQG LGRACGCAPG AAGGSEGPPP DCGCEPDLSL 370 380 390 400 410 420 AALGRLRYVD CVVKEVLRLL PPVSGGYRTA LRTFELDGYQ IPKGWSVMYS IRDTHETAAV 430 440 450 460 470 480 YRSPPEGFDP ERFGAAREDS RGASSRFHYI PFGGGARSCL GQELAQAVLQ LLAVELVRTA 490 500 510 520 RWELATPAFP AMQTVPIVHP VDGLRLFFHP LTPSVAGNGL CL

CATM prediction

The sequence of CP26C_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      10        20        30 
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 LSCLSVLGAAGTALLCAGLLLSLAQHL 7.3 -40.6° 1.9 44.1 -12.7

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 20, LEU, HA A, 19, LEU, O 3.31Å
B, 23, GLY, HA1 A, 20, LEU, O 3.17Å
B, 24, LEU, HA A, 23, GLY, O 3.42Å
B, 27, SER, HG1 A, 24, LEU, O 2.47Å
A, 20, LEU, HA B, 19, LEU, O 3.31Å
A, 23, GLY, HA1 B, 20, LEU, O 3.17Å
A, 24, LEU, HA B, 23, GLY, O 3.42Å
A, 27, SER, HG1 B, 24, LEU, O 2.47Å