Protein delta homolog 2

UniProt data

UniProt name: DLK2_HUMAN (Q6UY11)

Gene name: DLK2; Synonyms=EGFL9; ORFNames=UNQ2903/PRO28633

Organism: Homo sapiens (Human).

Function: Regulates adipogenesis. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 307-327, 21 AA, Helical. {ECO:0000255}.

Sequence: 383 AA

10 20 30 40 50 60 MPSGCRCLHL VCLLCILGAP GQPVRADDCS SHCDLAHGCC APDGSCRCDP GWEGLHCERC 70 80 90 100 110 120 VRMPGCQHGT CHQPWQCICH SGWAGKFCDK DEHICTTQSP CQNGGQCMYD GGGEYHCVCL 130 140 150 160 170 180 PGFHGRDCER KAGPCEQAGS PCRNGGQCQD DQGFALNFTC RCLVGFVGAR CEVNVDDCLM 190 200 210 220 230 240 RPCANGATCL DGINRFSCLC PEGFAGRFCT INLDDCASRP CQRGARCRDR VHDFDCLCPS 250 260 270 280 290 300 GYGGKTCELV LPVPDPPTTV DTPLGPTSAV VVPATGPAPH SAGAGLLRIS VKEVVRRQEA 310 320 330 340 350 360 GLGEPSLVAL VVFGALTAAL VLATVLLTLR AWRRGVCPPG PCCYPAPHYA PACQDQECQV 370 380 SMLPAGLPLP RDLPPEPGKT TAL

CATM prediction

The sequence of DLK2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        310       320       3
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 EASLVALVVFGALTAALVLATVLLTLR 7.2 -55.0° 0.3 45.2 -10.1
Prolines* EPSLVALVVFGALTAALVLATVLLTLR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 314, GLY, HA1 A, 311, VAL, O 3.37Å
B, 315, ALA, HA A, 314, GLY, O 3.35Å
A, 314, GLY, HA1 B, 311, VAL, O 3.37Å
A, 315, ALA, HA B, 314, GLY, O 3.35Å