Netrin receptor UNC5D

UniProt data

UniProt name: UNC5D_HUMAN (Q6UXZ4)

Gene name: UNC5D; Synonyms=KIAA1777, UNC5H4 {ECO:0000303|Ref.2}

Organism: Homo sapiens (Human).

Function: Receptor for the netrin NTN4 that promotes neuronal cell survival (By similarity). Plays a role in cell-cell adhesion and cell guidance. Receptor for netrin involved in cell migration. Plays a role in axon guidance by mediating axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding (By similarity). May play a role in apoptosis in response to DNA damage (PubMed:24691657). It also acts as a dependence receptor required for apoptosis induction when not associated with netrin ligand (PubMed:24519068). Mediates cell-cell adhesion via its interaction with FLRT3 on an adjacent cell (By similarity). {ECO:0000250|UniProtKB:Q8K1S2, ECO:0000305|PubMed:24519068, ECO:0000305|PubMed:24691657}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:26235030}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 380-400, 21 AA, Helical. {ECO:0000255}.

Sequence: 953 AA

10 20 30 40 50 60 MGRAAATAGG GGGARRWLPW LGLCFWAAGT AAARGTDNGE ALPESIPSAP GTLPHFIEEP 70 80 90 100 110 120 DDAYIIKSNP IALRCKARPA MQIFFKCNGE WVHQNEHVSE ETLDESSGLK VREVFINVTR 130 140 150 160 170 180 QQVEDFHGPE DYWCQCVAWS HLGTSKSRKA SVRIAYLRKN FEQDPQGREV PIEGMIVLHC 190 200 210 220 230 240 RPPEGVPAAE VEWLKNEEPI DSEQDENIDT RADHNLIIRQ ARLSDSGNYT CMAANIVAKR 250 260 270 280 290 300 RSLSATVVVY VNGGWSSWTE WSACNVRCGR GWQKRSRTCT NPAPLNGGAF CEGMSVQKIT 310 320 330 340 350 360 CTSLCPVDGS WEVWSEWSVC SPECEHLRIR ECTAPPPRNG GKFCEGLSQE SENCTDGLCI 370 380 390 400 410 420 LDKKPLHEIK PQSIENASDI ALYSGLGAAV VAVAVLVIGV TLYRRSQSDY GVDVIDSSAL 430 440 450 460 470 480 TGGFQTFNFK TVRQGNSLLL NSAMQPDLTV SRTYSGPICL QDPLDKELMT ESSLFNPLSD 490 500 510 520 530 540 IKVKVQSSFM VSLGVSERAE YHGKNHSRTF PHGNNHSFST MHPRNKMPYI QNLSSLPTRT 550 560 570 580 590 600 ELRTTGVFGH LGGRLVMPNT GVSLLIPHGA IPEENSWEIY MSINQGEPSL QSDGSEVLLS 610 620 630 640 650 660 PEVTCGPPDM IVTTPFALTI PHCADVSSEH WNIHLKKRTQ QGKWEEVMSV EDESTSCYCL 670 680 690 700 710 720 LDPFACHVLL DSFGTYALTG EPITDCAVKQ LKVAVFGCMS CNSLDYNLRV YCVDNTPCAF 730 740 750 760 770 780 QEVVSDERHQ GGQLLEEPKL LHFKGNTFSL QISVLDIPPF LWRIKPFTAC QEVPFSRVWC 790 800 810 820 830 840 SNRQPLHCAF SLERYTPTTT QLSCKICIRQ LKGHEQILQV QTSILESERE TITFFAQEDS 850 860 870 880 890 900 TFPAQTGPKA FKIPYSIRQR ICATFDTPNA KGKDWQMLAQ KNSINRNLSY FATQSSPSAV 910 920 930 940 950 ILNLWEARHQ HDGDLDSLAC ALEEIGRTHT KLSNISESQL DEADFNYSRQ NGL

CATM prediction

The sequence of UNC5D_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     380       390       400 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 ASDIALYSGLGAAVVAVAVLVIGVTLY 7.1 -39.8° 4.5 44.0 -16.8
Model 2 ASDIALYSGLGAAVVAVAVLVIGVTLY 7.3 -55.0° 2.4 48.0 -4.3
Model 3 ASDIALYSGLGAAVVAVAVLVIGVTLY 7.4 -22.0° 3.1 40.0 -2.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 382, LEU, HA A, 381, ALA, O 2.98Å
B, 385, GLY, HA1 A, 382, LEU, O 3.35Å
A, 382, LEU, HA B, 381, ALA, O 2.98Å
A, 385, GLY, HA1 B, 382, LEU, O 3.35Å