UniProt data
UniProt name: IZUM2_HUMAN (Q6UXV1)
Gene name: IZUMO2; Synonyms=C19orf41, SCRL; ORFNames=UNQ6978/PRO21961
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 187-207, 21 AA, Helical. {ECO:0000255}.
Sequence: 221 AA
10 20 30 40 50 60
MPLALTLLLL SGLGAPGGWG CLQCDPLVLE ALGHLRSALI PSRFQLEQLQ ARAGAVLMGM
70 80 90 100 110 120
EGPFFRDYAL NVFVGKVETN QLDLVASFVK NQTQHLMGNS LKDEPLLEEL VTLRANVIKE
130 140 150 160 170 180
FKKVLISYEL KACNPKLCRL LKEEVLDCLH CQRITPKCIH KKYCFVDRQP RVALQYQMDS
190 200 210 220
KYPRNQALLG ILISVSLAVF VFVVIVVSAC TYRQNRKLLL Q
CATM prediction
The sequence of IZUM2_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 190 200 2 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RNQALLGILISVSLAVFVFVVIVVSAC | 6.8 | -46.0° | 4.7 | 37.8 | -15.6 |
| Model 2 | RNQALLGILISVSLAVFVFVVIVVSAC | 7.3 | -37.3° | 2.2 | 36.0 | -4.3 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 190, GLY, HA1 | A, 187, ALA, O | 3.03Å |
| B, 191, ILE, HA | A, 194, SER, OG | 3.45Å |
| B, 194, SER, HG1 | A, 194, SER, OG | 1.92Å |
| A, 190, GLY, HA1 | B, 187, ALA, O | 3.03Å |
