C-type lectin domain family 9 member A

UniProt data

UniProt name: CLC9A_HUMAN (Q6UXN8)

Gene name: CLEC9A; ORFNames=UNQ9341/PRO34046

Organism: Homo sapiens (Human).

Function: Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. {ECO:0000269|PubMed:18497879, ECO:0000269|PubMed:22483802}.

Subcellular location: Membrane {ECO:0000269|PubMed:18408006}; Single-pass type II membrane protein {ECO:0000269|PubMed:18408006}.

Transmembrane domains:

  1. 36-56, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 241 AA

10 20 30 40 50 60 MHEEEIYTSL QWDSPAPDTY QKCLSSNKCS GACCLVMVIS CVFCMGLLTA SIFLGVKLLQ 70 80 90 100 110 120 VSTIAMQQQE KLIQQERALL NFTEWKRSCA LQMKYCQAFM QNSLSSAHNS SPCPNNWIQN 130 140 150 160 170 180 RESCYYVSEI WSIWHTSQEN CLKEGSTLLQ IESKEEMDFI TGSLRKIKGS YDYWVGLSQD 190 200 210 220 230 240 GHSGRWLWQD GSSPSPGLLP AERSQSANQV CGYVKSNSLL SSNCSTWKYF ICEKYALRSS V

CATM prediction

The sequence of CLC9A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         40        50        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 CCLVMVISCVFCMGLLTASIFLGVKLL 7.4 -49.7° 2.9 46.5 -7.2

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 43, PHE, HA A, 42, VAL, O 3.40Å
B, 46, GLY, HA1 A, 43, PHE, O 3.30Å
A, 43, PHE, HA B, 42, VAL, O 3.40Å
A, 46, GLY, HA1 B, 43, PHE, O 3.30Å