Leucine-rich repeats and immunoglobulin-like domains protein 3

UniProt data

UniProt name: LRIG3_HUMAN (Q6UXM1)

Gene name: LRIG3; Synonyms=LIG3; ORFNames=UNQ287/PRO326/PRO335

Organism: Homo sapiens (Human).

Function: May play a role in craniofacial and inner ear morphogenesis during embryonic development. May act within the otic vesicle epithelium to control formation of the lateral semicircular canal in the inner ear, possibly by restricting the expression of NTN1 (By similarity). {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cytoplasmic vesicle membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Note=Detected in cytoplasmic vesicles when coexpressed with ERBB4. {ECO:0000250}.

Transmembrane domains:

  1. 810-830, 21 AA, Helical. {ECO:0000255}.

Sequence: 1119 AA

10 20 30 40 50 60 MSAPSLRARA AGLGLLLCAV LGRAGRSDSG GRGELGQPSG VAAERPCPTT CRCLGDLLDC 70 80 90 100 110 120 SRKRLARLPE PLPSWVARLD LSHNRLSFIK ASSMSHLQSL REVKLNNNEL ETIPNLGPVS 130 140 150 160 170 180 ANITLLSLAG NRIVEILPEH LKEFQSLETL DLSSNNISEL QTAFPALQLK YLYLNSNRVT 190 200 210 220 230 240 SMEPGYFDNL ANTLLVLKLN RNRISAIPPK MFKLPQLQHL ELNRNKIKNV DGLTFQGLGA 250 260 270 280 290 300 LKSLKMQRNG VTKLMDGAFW GLSNMEILQL DHNNLTEITK GWLYGLLMLQ ELHLSQNAIN 310 320 330 340 350 360 RISPDAWEFC QKLSELDLTF NHLSRLDDSS FLGLSLLNTL HIGNNRVSYI ADCAFRGLSS 370 380 390 400 410 420 LKTLDLKNNE ISWTIEDMNG AFSGLDKLRR LILQGNRIRS ITKKAFTGLD ALEHLDLSDN 430 440 450 460 470 480 AIMSLQGNAF SQMKKLQQLH LNTSSLLCDC QLKWLPQWVA ENNFQSFVNA SCAHPQLLKG 490 500 510 520 530 540 RSIFAVSPDG FVCDDFPKPQ ITVQPETQSA IKGSNLSFIC SAASSSDSPM TFAWKKDNEL 550 560 570 580 590 600 LHDAEMENYA HLRAQGGEVM EYTTILRLRE VEFASEGKYQ CVISNHFGSS YSVKAKLTVN 610 620 630 640 650 660 MLPSFTKTPM DLTIRAGAMA RLECAAVGHP APQIAWQKDG GTDFPAARER RMHVMPEDDV 670 680 690 700 710 720 FFIVDVKIED IGVYSCTAQN SAGSISANAT LTVLETPSFL RPLLDRTVTK GETAVLQCIA 730 740 750 760 770 780 GGSPPPKLNW TKDDSPLVVT ERHFFAAGNQ LLIIVDSDVS DAGKYTCEMS NTLGTERGNV 790 800 810 820 830 840 RLSVIPTPTC DSPQMTAPSL DDDGWATVGV VIIAVVCCVV GTSLVWVVII YHTRRRNEDC 850 860 870 880 890 900 SITNTDETNL PADIPSYLSS QGTLADRQDG YVSSESGSHH QFVTSSGAGF FLPQHDSSGT 910 920 930 940 950 960 CHIDNSSEAD VEAATDLFLC PFLGSTGPMY LKGNVYGSDP FETYHTGCSP DPRTVLMDHY 970 980 990 1000 1010 1020 EPSYIKKKEC YPCSHPSEES CERSFSNISW PSHVRKLLNT SYSHNEGPGM KNLCLNKSSL 1030 1040 1050 1060 1070 1080 DFSANPEPAS VASSNSFMGT FGKALRRPHL DAYSSFGQPS DCQPRAFYLK AHSSPDLDSG 1090 1100 1110 SEEDGKERTD FQEENHICTF KQTLENYRTP NFQSYDLDT

CATM prediction

The sequence of LRIG3_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     810       820       830 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 TVGVVIIAVVCCVVGTSLVWVVIIYHT 7.3 -51.0° 3.3 48.0 -27.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 818, CYS, HA A, 817, CYS, O 3.20Å
B, 821, GLY, HA1 A, 818, CYS, O 3.31Å
A, 818, CYS, HA B, 817, CYS, O 3.20Å
A, 821, GLY, HA1 B, 818, CYS, O 3.31Å