UPF0577 protein KIAA1324

UniProt data

UniProt name: K1324_HUMAN (Q6UXG2)

Gene name: KIAA1324; Synonyms=EIG121; ORFNames=UNQ2426/PRO4985

Organism: Homo sapiens (Human).

Function: May protect cells from cell death by inducing cytosolic vacuolization and upregulating the autophagy pathway. {ECO:0000269|PubMed:21072319}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Late endosome membrane {ECO:0000269|PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:21072319}; Single-pass type I membrane protein {ECO:0000269|PubMed:21072319}. Lysosome membrane {ECO:0000269|PubMed:21072319}; Single-pass membrane protein {ECO:0000269|PubMed:21072319}.

Transmembrane domains:

  1. 911-931, 21 AA, Helical. {ECO:0000255}.

Sequence: 1013 AA

10 20 30 40 50 60 MAEPGHSHHL SARVRGRTER RIPRLWRLLL WAGTAFQVTQ GTGPELHACK ESEYHYEYTA 70 80 90 100 110 120 CDSTGSRWRV AVPHTPGLCT SLPDPIKGTE CSFSCNAGEF LDMKDQSCKP CAEGRYSLGT 130 140 150 160 170 180 GIRFDEWDEL PHGFASLSAN MELDDSAAES TGNCTSSKWV PRGDYIASNT DECTATLMYA 190 200 210 220 230 240 VNLKQSGTVN FEYYYPDSSI IFEFFVQNDQ CQPNADDSRW MKTTEKGWEF HSVELNRGNN 250 260 270 280 290 300 VLYWRTTAFS VWTKVPKPVL VRNIAITGVA YTSECFPCKP GTYADKQGSS FCKLCPANSY 310 320 330 340 350 360 SNKGETSCHQ CDPDKYSEKG SSSCNVRPAC TDKDYFYTHT ACDANGETQL MYKWAKPKIC 370 380 390 400 410 420 SEDLEGAVKL PASGVKTHCP PCNPGFFKTN NSTCQPCPYG SYSNGSDCTR CPAGTEPAVG 430 440 450 460 470 480 FEYKWWNTLP TNMETTVLSG INFEYKGMTG WEVAGDHIYT AAGASDNDFM ILTLVVPGFR 490 500 510 520 530 540 PPQSVMADTE NKEVARITFV FETLCSVNCE LYFMVGVNSR TNTPVETWKG SKGKQSYTYI 550 560 570 580 590 600 IEENTTTSFT WAFQRTTFHE ASRKYTNDVA KIYSINVTNV MNGVASYCRP CALEASDVGS 610 620 630 640 650 660 SCTSCPAGYY IDRDSGTCHS CPTNTILKAH QPYGVQACVP CGPGTKNNKI HSLCYNDCTF 670 680 690 700 710 720 SRNTPTRTFN YNFSALANTV TLAGGPSFTS KGLKYFHHFT LSLCGNQGRK MSVCTDNVTD 730 740 750 760 770 780 LRIPEGESGF SKSITAYVCQ AVIIPPEVTG YKAGVSSQPV SLADRLIGVT TDMTLDGITS 790 800 810 820 830 840 PAELFHLESL GIPDVIFFYR SNDVTQSCSS GRSTTIRVRC SPQKTVPGSL LLPGTCSDGT 850 860 870 880 890 900 CDGCNFHFLW ESAAACPLCS VADYHAIVSS CVAGIQKTTY VWREPKLCSG GISLPEQRVT 910 920 930 940 950 960 ICKTIDFWLK VGISAGTCTA ILLTVLTCYF WKKNQKLEYK YSKLVMNATL KDCDLPAADS 970 980 990 1000 1010 CAIMEGEDVE DDLIFTSKKS LFGKIKSFTS KRTPDGFDSV PLKTSSGGLD MDL

CATM prediction

The sequence of K1324_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    910       920       930  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 WLKVGISAGTCTAILLTVLTCYFWKKN 6.5 -43.0° 5.4 59.9 -25.2
Model 2 WLKVGISAGTCTAILLTVLTCYFWKKN 7.0 -26.0° 3.6 54.0 -22.7
Model 3 WLKVGISAGTCTAILLTVLTCYFWKKN 7.2 -55.0° 0.3 44.8 -20.2
Model 4 WLKVGISAGTCTAILLTVLTCYFWKKN 7.1 -43.2° 2.4 43.9 -15.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 913, ILE, HA A, 912, GLY, O 2.53Å
B, 916, GLY, HA1 A, 913, ILE, O 3.36Å
A, 913, ILE, HA B, 912, GLY, O 2.53Å
A, 916, GLY, HA1 B, 913, ILE, O 3.36Å