Butyrophilin-like protein 8

UniProt data

UniProt name: BTNL8_HUMAN (Q6UX41)

Gene name: BTNL8; ORFNames=UNQ702/PRO1347

Organism: Homo sapiens (Human).

Function: May stimulate primary immune response. Acts on T-cell stimulated sub-optimally through the TCR/CD3 complex stimulating their proliferation and cytokine production. {ECO:0000269|PubMed:24036152}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 239-259, 21 AA, Helical. {ECO:0000255}.

Sequence: 500 AA

10 20 30 40 50 60 MALMLSLVLS LLKLGSGQWQ VFGPDKPVQA LVGEDAAFSC FLSPKTNAEA MEVRFFRGQF 70 80 90 100 110 120 SSVVHLYRDG KDQPFMQMPQ YQGRTKLVKD SIAEGRISLR LENITVLDAG LYGCRISSQS 130 140 150 160 170 180 YYQKAIWELQ VSALGSVPLI SITGYVDRDI QLLCQSSGWF PRPTAKWKGP QGQDLSTDSR 190 200 210 220 230 240 TNRDMHGLFD VEISLTVQEN AGSISCSMRH AHLSREVESR VQIGDTFFEP ISWHLATKVL 250 260 270 280 290 300 GILCCGLFFG IVGLKIFFSK FQWKIQAELD WRRKHGQAEL RDARKHAVEV TLDPETAHPK 310 320 330 340 350 360 LCVSDLKTVT HRKAPQEVPH SEKRFTRKSV VASQSFQAGK HYWEVDGGHN KRWRVGVCRD 370 380 390 400 410 420 DVDRRKEYVT LSPDHGYWVL RLNGEHLYFT LNPRFISVFP RTPPTKIGVF LDYECGTISF 430 440 450 460 470 480 FNINDQSLIY TLTCRFEGLL RPYIEYPSYN EQNGTPIVIC PVTQESEKEA SWQRASAIPE 490 TSNSESSSQA TTPFLPRGEM

CATM prediction

The sequence of BTNL8_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      240       250       260
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 ATKVLGILCCGLFFGIVGLKIFFSKFQ 6.5 +53.2° 2.7 87.7 -5.1

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 247, LEU, HA A, 246, GLY, O 3.05Å
B, 250, GLY, HA1 A, 246, GLY, O 3.01Å
B, 250, GLY, HA2 A, 249, PHE, O 3.15Å
A, 247, LEU, HA B, 246, GLY, O 3.05Å
A, 250, GLY, HA1 B, 246, GLY, O 3.01Å
A, 250, GLY, HA2 B, 249, PHE, O 3.15Å