UniProt data
UniProt name: KIRR2_HUMAN (Q6UWL6)
Gene name: KIRREL2; Synonyms=NEPH3; ORFNames=UNQ5827/PRO19646
Organism: Homo sapiens (Human).
Function:
Subcellular location: Cell membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 511-531, 21 AA, Helical. {ECO:0000255}.
Sequence: 708 AA
10 20 30 40 50 60
MLRMRVPALL VLLFCFRGRA GPSPHFLQQP EDLVVLLGEE ARLPCALGAY WGLVQWTKSG
70 80 90 100 110 120
LALGGQRDLP GWSRYWISGN AANGQHDLHI RPVELEDEAS YECQATQAGL RSRPAQLHVL
130 140 150 160 170 180
VPPEAPQVLG GPSVSLVAGV PANLTCRSRG DARPTPELLW FRDGVLLDGA TFHQTLLKEG
190 200 210 220 230 240
TPGSVESTLT LTPFSHDDGA TFVCRARSQA LPTGRDTAIT LSLQYPPEVT LSASPHTVQE
250 260 270 280 290 300
GEKVIFLCQA TAQPPVTGYR WAKGGSPVLG ARGPRLEVVA DASFLTEPVS CEVSNAVGSA
310 320 330 340 350 360
NRSTALDVLF GPILQAKPEP VSVDVGEDAS FSCAWRGNPL PRVTWTRRGG AQVLGSGATL
370 380 390 400 410 420
RLPSVGPEDA GDYVCRAEAG LSGLRGGAAE ARLTVNAPPV VTALHSAPAF LRGPARLQCL
430 440 450 460 470 480
VFASPAPDAV VWSWDEGFLE AGSQGRFLVE TFPAPESRGG LGPGLISVLH ISGTQESDFS
490 500 510 520 530 540
RSFNCSARNR LGEGGAQASL GRRDLLPTVR IVAGVAAATT TLLMVITGVA LCCWRHSKAS
550 560 570 580 590 600
ASFSEQKNLM RIPGSSDGSS SRGPEEEETG SREDRGPIVH TDHSDLVLEE KGTLETKDPT
610 620 630 640 650 660
NGYYKVRGVS VSLSLGEAPG GGLFLPPPSP LGPPGTPTFY DFNPHLGMVP PCRLYRARAG
670 680 690 700
YLTTPHPRAF TSYIKPTSFG PPDLAPGTPP FPYAAFPTPS HPRLQTHV
CATM prediction
The sequence of KIRR2_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 510 520 530 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | TVRIVAGVAAATTTLLMVITGVALCCW | 7.1 | -49.9° | 2.9 | 46.9 | -29.0 |
| Model 2 | TVRIVAGVAAATTTLLMVITGVALCCW | 7.4 | -49.0° | 3.9 | 38.3 | -23.8 |
| Model 3 | TVRIVAGVAAATTTLLMVITGVALCCW | 7.1 | -40.0° | 2.7 | 33.7 | -11.5 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 525, VAL, HA | A, 524, MET, O | 3.21Å |
| B, 528, GLY, HA1 | A, 525, VAL, O | 3.13Å |
| A, 525, VAL, HA | B, 524, MET, O | 3.21Å |
| A, 528, GLY, HA1 | B, 525, VAL, O | 3.13Å |
