Protein shisa-2 homolog

UniProt data

UniProt name: SHSA2_HUMAN (Q6UWI4)

Gene name: SHISA2; Synonyms=C13orf13, TMEM46; ORFNames=UNQ9166/PRO28631

Organism: Homo sapiens (Human).

Function: Plays an essential role in the maturation of presomitic mesoderm cells by individual attenuation of both FGF and WNT signaling. {ECO:0000250}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 111-131, 21 AA, Helical. {ECO:0000255}.

Sequence: 295 AA

10 20 30 40 50 60 MWGARRSSVS SSWNAASLLQ LLLAALLAAG ARASGEYCHG WLDAQGVWRI GFQCPERFDG 70 80 90 100 110 120 GDATICCGSC ALRYCCSSAE ARLDQGGCDN DRQQGAGEPG RADKDGPDGS AVPIYVPFLI 130 140 150 160 170 180 VGSVFVAFII LGSLVAACCC RCLRPKQDPQ QSRAPGGNRL METIPMIPSA STSRGSSSRQ 190 200 210 220 230 240 SSTAASSSSS ANSGARAPPT RSQTNCCLPE GTMNNVYVNM PTNFSVLNCQ QATQIVPHQG 250 260 270 280 290 QYLHPPYVGY TVQHDSVPMT AVPPFMDGLQ PGYRQIQSPF PHTNSEQKMY PAVTV

CATM prediction

The sequence of SHSA2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    110       120       130  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 DGSAVAIYVAFLIVGSVFVAFIILGSL 7.4 -46.0° 3.6 37.4 -2.3
Prolines* DGSAVPIYVPFLIVGSVFVAFIILGSL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 119, LEU, HA A, 118, PHE, O 3.40Å
B, 122, GLY, HA1 A, 119, LEU, O 3.44Å
A, 119, LEU, HA B, 118, PHE, O 3.40Å
A, 122, GLY, HA1 B, 119, LEU, O 3.44Å