UniProt data
UniProt name: F198B_HUMAN (Q6UWH4)
Gene name: FAM198B; Synonyms=C4orf18, ENED; ORFNames=AD021, UNQ2512/PRO6001
Organism: Homo sapiens (Human).
Function:
Subcellular location: Golgi apparatus membrane {ECO:0000305|PubMed:11256614}; Single-pass type II membrane protein {ECO:0000305|PubMed:11256614}.
Transmembrane domains:
- 38-55, 18 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.
Sequence: 519 AA
10 20 30 40 50 60
MTCPDKPGQL INWFICSLCV PRVRKLWSSR RPRTRRNLLL GTACAIYLGF LVSQVGRASL
70 80 90 100 110 120
QHGQAAEKGP HRSRDTAEPS FPEIPLDGTL APPESQGNGS TLQPNVVYIT LRSKRSKPAN
130 140 150 160 170 180
IRGTVKPKRR KKHAVASAAP GQEALVGPSL QPQEAAREAD AVAPGYAQGA NLVKIGERPW
190 200 210 220 230 240
RLVRGPGVRA GGPDFLQPSS RESNIRIYSE SAPSWLSKDD IRRMRLLADS AVAGLRPVSS
250 260 270 280 290 300
RSGARLLVLE GGAPGAVLRC GPSPCGLLKQ PLDMSEVFAF HLDRILGLNR TLPSVSRKAE
310 320 330 340 350 360
FIQDGRPCPI ILWDASLSSA SNDTHSSVKL TWGTYQQLLK QKCWQNGRVP KPESGCTEIH
370 380 390 400 410 420
HHEWSKMALF DFLLQIYNRL DTNCCGFRPR KEDACVQNGL RPKCDDQGSA ALAHIIQRKH
430 440 450 460 470 480
DPRHLVFIDN KGFFDRSEDN LNFKLLEGIK EFPASAVSVL KSQHLRQKLL QSLFLDKVYW
490 500 510
ESQGGRQGIE KLIDVIEHRA KILITYINAH GVKVLPMNE
CATM prediction
The sequence of F198B_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 40 50 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RRNLLLGTACAIYLGFLVSQVGRA | 6.9 | -46.3° | 2.3 | 44.8 | -21.4 |
| Model 2 | RRNLLLGTACAIYLGFLVSQVGRA | 7.2 | -36.0° | 3.6 | 36.0 | -21.0 |
| Model 3 | RRNLLLGTACAIYLGFLVSQVGRA | 7.0 | -45.0° | 5.5 | 45.0 | -2.0 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 46, ILE, HA | A, 45, ALA, O | 3.05Å |
| B, 49, GLY, HA1 | A, 46, ILE, O | 2.87Å |
| B, 50, PHE, HA | A, 49, GLY, O | 3.33Å |
| B, 53, SER, HG1 | A, 50, PHE, O | 2.63Å |
| A, 46, ILE, HA | B, 45, ALA, O | 3.05Å |
| A, 49, GLY, HA1 | B, 46, ILE, O | 2.87Å |
| A, 50, PHE, HA | B, 49, GLY, O | 3.33Å |
| A, 53, SER, HG1 | B, 50, PHE, O | 2.63Å |
