UniProt data
UniProt name: SCIMP_HUMAN (Q6UWF3)
Gene name: SCIMP; Synonyms=C17orf87; ORFNames=UNQ5783/PRO16090
Organism: Homo sapiens (Human).
Function: Lipid tetraspanin-associated transmembrane adapter/mediator involved in major histocompatibility complex (MHC) class II signaling transduction. Required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation. {ECO:0000269|PubMed:21930792}.
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Membrane {ECO:0000269|PubMed:21930792}; Lipid-anchor {ECO:0000269|PubMed:21930792}. Note=Together with MHC-II, associates with lipid-enriched microdomains called tetraspanin-enriched microdomains (TEMs). Rapidly translocates into immunological synapse (IS) at cell-cell contacts between antigen-presenting cells (APCs) and T-cells. Colocalized with tetraspanins CD37, CD53, and CD81 at the uropod. Present at regions of cell-cell contacts but also at the leading edge of migrating cells.
Transmembrane domains:
- 19-39, 21 AA, Helical. {ECO:0000255}.
Sequence: 145 AA
CATM prediction
The sequence of SCIMP_HUMAN returned 1 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 20 30 40 | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RNNFWIILAVAIIVVSVGLGLILYCVC | 7.3 | -54.1° | 3.6 | 49.0 | -5.1 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 28, ILE, HA | A, 31, SER, OG | 3.12Å |
| B, 32, VAL, HA | A, 31, SER, O | 3.29Å |
| B, 35, GLY, HA1 | A, 32, VAL, O | 3.42Å |
| A, 28, ILE, HA | B, 31, SER, OG | 3.12Å |
| A, 32, VAL, HA | B, 31, SER, O | 3.29Å |
| A, 35, GLY, HA1 | B, 32, VAL, O | 3.42Å |