Interleukin-27 receptor subunit alpha

UniProt data

UniProt name: I27RA_HUMAN (Q6UWB1)

Gene name: IL27RA; Synonyms=CRL1, TCCR, WSX1; ORFNames=UNQ296/PRO336

Organism: Homo sapiens (Human).

Function: Receptor for IL27. Requires IL6ST/gp130 to mediate signal transduction in response to IL27. This signaling system acts through STAT3 and STAT1. Involved in the regulation of Th1- type immune responses. Also appears to be involved in innate defense mechanisms. {ECO:0000269|PubMed:14764690}.

Subcellular location: Membrane; Single-pass type I membrane protein.

Transmembrane domains:

  1. 517-537, 21 AA, Helical. {ECO:0000255}.

Sequence: 636 AA

10 20 30 40 50 60 MRGGRGAPFW LWPLPKLALL PLLWVLFQRT RPQGSAGPLQ CYGVGPLGDL NCSWEPLGDL 70 80 90 100 110 120 GAPSELHLQS QKYRSNKTQT VAVAAGRSWV AIPREQLTMS DKLLVWGTKA GQPLWPPVFV 130 140 150 160 170 180 NLETQMKPNA PRLGPDVDFS EDDPLEATVH WAPPTWPSHK VLICQFHYRR CQEAAWTLLE 190 200 210 220 230 240 PELKTIPLTP VEIQDLELAT GYKVYGRCRM EKEEDLWGEW SPILSFQTPP SAPKDVWVSG 250 260 270 280 290 300 NLCGTPGGEE PLLLWKAPGP CVQVSYKVWF WVGGRELSPE GITCCCSLIP SGAEWARVSA 310 320 330 340 350 360 VNATSWEPLT NLSLVCLDSA SAPRSVAVSS IAGSTELLVT WQPGPGEPLE HVVDWARDGD 370 380 390 400 410 420 PLEKLNWVRL PPGNLSALLP GNFTVGVPYR ITVTAVSASG LASASSVWGF REELAPLVGP 430 440 450 460 470 480 TLWRLQDAPP GTPAIAWGEV PRHQLRGHLT HYTLCAQSGT SPSVCMNVSG NTQSVTLPDL 490 500 510 520 530 540 PWGPCELWVT ASTIAGQGPP GPILRLHLPD NTLRWKVLPG ILFLWGLFLL GCGLSLATSG 550 560 570 580 590 600 RCYHLRHKVL PRWVWEKVPD PANSSSGQPH MEQVPEAQPL GDLPILEVEE MEPPPVMESS 610 620 630 QPAQATAPLD SGYEKHFLPT PEELGLLGPP RPQVLA

CATM prediction

The sequence of I27RA_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        520       530       5
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 RWKVLAGILFLWGLFLLGCGLSLATSG 7.3 -40.0° 1.9 44.1 -11.0
Model 2 RWKVLAGILFLWGLFLLGCGLSLATSG 6.9 -55.0° 0.9 50.1 -8.2
Prolines* RWKVLPGILFLWGLFLLGCGLSLATSG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 530, LEU, HA A, 529, LEU, O 3.31Å
B, 533, GLY, HA1 A, 530, LEU, O 3.18Å
B, 534, LEU, HA A, 533, GLY, O 3.40Å
A, 530, LEU, HA B, 529, LEU, O 3.31Å
A, 533, GLY, HA1 B, 530, LEU, O 3.18Å
A, 534, LEU, HA B, 533, GLY, O 3.40Å