Epigen

UniProt data

UniProt name: EPGN_HUMAN (Q6UW88)

Gene name: EPGN; ORFNames=UNQ3072/PRO9904

Organism: Homo sapiens (Human).

Function: Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases. {ECO:0000269|PubMed:15611079}.

Subcellular location: Isoform 6: Secreted {ECO:0000305}.

Transmembrane domains:

  1. 111-131, 21 AA, Helical. {ECO:0000255}.

Sequence: 154 AA

10 20 30 40 50 60 MALGVPISVY LLFNAMTALT EEAAVTVTPP ITAQQGNWTV NKTEADNIEG PIALKFSHLC 70 80 90 100 110 120 LEDHNSYCIN GACAFHHELE KAICRCFTGY TGERCEHLTL TSYAVDSYEK YIAIGIGVGL 130 140 150 LLSGFLVIFY CYIRKRCLKL KSPYNVCSGE RRPL

CATM prediction

The sequence of EPGN_HUMAN returned 4 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    110       120       130  
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 YEKYIAIGIGVGLLLSGFLVIFYCYIR 6.5 -42.6° 5.4 59.9 -51.6
Model 2 YEKYIAIGIGVGLLLSGFLVIFYCYIR 7.2 -40.2° 2.7 34.4 -33.3
Model 3 YEKYIAIGIGVGLLLSGFLVIFYCYIR 7.1 -55.1° 2.4 47.7 -26.1
Model 4 YEKYIAIGIGVGLLLSGFLVIFYCYIR 7.1 -43.8° 1.8 45.0 -24.6

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 112, ILE, HA A, 111, TYR, O 3.26Å
B, 115, GLY, HA1 A, 112, ILE, O 2.88Å
B, 116, ILE, HA A, 115, GLY, O 2.54Å
B, 119, GLY, HA1 A, 116, ILE, O 3.39Å
A, 112, ILE, HA B, 111, TYR, O 3.26Å
A, 115, GLY, HA1 B, 112, ILE, O 2.88Å
A, 116, ILE, HA B, 115, GLY, O 2.54Å
A, 119, GLY, HA1 B, 116, ILE, O 3.39Å