Ubiquinol-cytochrome-c reductase complex assembly factor 3 {ECO:0000312|HGNC:HGNC:34399}

UniProt data

UniProt name: UQCC3_HUMAN (Q6UW78)

Gene name: UQCC3 {ECO:0000312|HGNC:HGNC:34399}

Organism: Homo sapiens (Human).

Function: Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin- binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}; Single-pass membrane protein {ECO:0000269|PubMed:25008109, ECO:0000269|PubMed:25605331}.

Transmembrane domains:

  1. 8-28, 21 AA, Helical. {ECO:0000255}.

Sequence: 93 AA

10 20 30 40 50 60 MDSLRKMLIS VAMLGAGAGV GYALLVIVTP GERRKQEMLK EMPLQDPRSR EEAARTQQLL 70 80 90 LATLQEAATT QENVAWRKNW MVGGEGGAGG RSP

CATM prediction

The sequence of UQCC3_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       10        20        30
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 RKMLISVAMLGAGAGVGYALLVIVTAG 6.4 -54.8° 5.8 46.9 -35.2
Model 2 RKMLISVAMLGAGAGVGYALLVIVTAG 6.6 -41.2° 0.6 42.8 -32.2
Model 3 RKMLISVAMLGAGAGVGYALLVIVTAG 6.9 -43.1° -0.0 34.2 -19.4
Model 4 RKMLISVAMLGAGAGVGYALLVIVTAG 7.4 -43.1° 3.4 50.1 -14.7
Model 5 RKMLISVAMLGAGAGVGYALLVIVTAG 6.6 -54.8° 1.5 45.1 -13.3
Model 6 RKMLISVAMLGAGAGVGYALLVIVTAG 7.0 -51.9° 1.8 35.4 -8.6
Model 7 RKMLISVAMLGAGAGVGYALLVIVTAG 7.0 -55.0° 2.4 48.0 -6.3
Prolines* RKMLISVAMLGAGAGVGYALLVIVTPG          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 17, GLY, HA1 A, 14, LEU, O 2.80Å
B, 18, ALA, HA A, 17, GLY, O 2.49Å
B, 21, GLY, HA1 A, 18, ALA, O 3.28Å
B, 21, GLY, HA2 A, 22, TYR, OH 3.12Å
A, 17, GLY, HA1 B, 14, LEU, O 2.80Å
A, 18, ALA, HA B, 17, GLY, O 2.49Å
A, 21, GLY, HA1 B, 18, ALA, O 3.28Å