Proprotein convertase subtilisin/kexin type 4

UniProt data

UniProt name: PCSK4_HUMAN (Q6UW60)

Gene name: PCSK4 {ECO:0000312|EMBL:AAH36354.1}

Organism: Homo sapiens (Human).

Function: Proprotein convertase involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues (By similarity). In males, important for ADAM2 processing as well as other acrosomal proteins with roles in fertilization and critical for normal fertilization events such as sperm capacitation, acrosome reaction and binding of sperm to zona pellucida (By similarity). Plays also a role in female fertility, involved in the regulation of trophoblast migration and placental development, may be through the proteolytical processing and activation of proteins such as IGF2 (PubMed:16040806). May also participate in folliculogenesis in the ovaries (By similarity). {ECO:0000250|UniProtKB:P29121, ECO:0000269|PubMed:16040806}.

Subcellular location: Membrane {ECO:0000255}; Single-pass membrane protein {ECO:0000255}. Cytoplasmic vesicle, secretory vesicle, acrosome membrane {ECO:0000250|UniProtKB:P29121}.

Transmembrane domains:

  1. 709-729, 21 AA, Helical. {ECO:0000255}.

Sequence: 755 AA

10 20 30 40 50 60 MRPAPIALWL RLVLALALVR PRAVGWAPVR APIYVSSWAV QVSQGNREVE RLARKFGFVN 70 80 90 100 110 120 LGPIFPDGQY FHLRHRGVVQ QSLTPHWGHR LHLKKNPKVQ WFQQQTLQRR VKRSVVVPTD 130 140 150 160 170 180 PWFSKQWYMN SEAQPDLSIL QAWSQGLSGQ GIVVSVLDDG IEKDHPDLWA NYDPLASYDF 190 200 210 220 230 240 NDYDPDPQPR YTPSKENRHG TRCAGEVAAM ANNGFCGVGV AFNARIGGVR MLDGTITDVI 250 260 270 280 290 300 EAQSLSLQPQ HIHIYSASWG PEDDGRTVDG PGILTREAFR RGVTKGRGGL GTLFIWASGN 310 320 330 340 350 360 GGLHYDNCNC DGYTNSIHTL SVGSTTQQGR VPWYSEACAS TLTTTYSSGV ATDPQIVTTD 370 380 390 400 410 420 LHHGCTDQHT GTSASAPLAA GMIALALEAN PFLTWRDMQH LVVRASKPAH LQAEDWRTNG 430 440 450 460 470 480 VGRQVSHHYG YGLLDAGLLV DTARTWLPTQ PQRKCAVRVQ SRPTPILPLI YIRENVSACA 490 500 510 520 530 540 GLHNSIRSLE HVQAQLTLSY SRRGDLEISL TSPMGTRSTL VAIRPLDVST EGYNNWVFMS 550 560 570 580 590 600 THFWDENPQG VWTLGLENKG YYFNTGTLYR YTLLLYGTAE DMTARPTGPQ VTSSACVQRD 610 620 630 640 650 660 TEGLCQACDG PAYILGQLCL AYCPPRFFNH TRLVTAGPGH TAAPALRVCS SCHASCYTCR 670 680 690 700 710 720 GGSPRDCTSC PPSSTLDQQQ GSCMGPTTPD SRPRLRAAAC PHHRCPASAM VLSLLAVTLG 730 740 750 GPVLCGMSMD LPLYAWLSRA RATPTKPQVW LPAGT

CATM prediction

The sequence of PCSK4_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      710       720       730
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 AASAMVLSLLAVTLGGAVLCGMSMDLA 7.0 -49.9° 2.9 47.0 -19.2
Model 2 AASAMVLSLLAVTLGGAVLCGMSMDLA 6.9 -51.0° 1.2 45.0 -13.2
Prolines* PASAMVLSLLAVTLGGPVLCGMSMDLP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 723, VAL, HA A, 722, ALA, O 3.05Å
B, 726, GLY, HA1 A, 723, VAL, O 2.99Å
A, 723, VAL, HA B, 722, ALA, O 3.05Å
A, 726, GLY, HA1 B, 723, VAL, O 2.99Å