All-trans retinoic acid-induced differentiation factor

UniProt data

UniProt name: ARAID_HUMAN (Q6UW56)

Gene name: ATRAID; Synonyms=APR3, C2orf28; ORFNames=HSPC013, UNQ214/PRO240

Organism: Homo sapiens (Human).

Function: Promotes osteoblast cell differentiation and terminal mineralization. Plays a role in inducing the cell cycle arrest via inhibiting CCND1 expression in all-trans-retinoic acid (ATRA) signal pathway. {ECO:0000269|PubMed:21723284}.

Subcellular location: Nucleus envelope {ECO:0000269|PubMed:21723284}. Cell membrane {ECO:0000269|PubMed:17524364}; Single-pass membrane protein {ECO:0000269|PubMed:17524364}. Note=Colocalizes with NELL1 on the nuclear envelope and the perinuclear region (PubMed:21723284).

Transmembrane domains:

  1. 200-220, 21 AA, Helical. {ECO:0000255}.

Sequence: 229 AA

10 20 30 40 50 60 MAPHDPGSLT TLVPWAAALL LALGVERALA LPEICTQCPG SVQNLSKVAF YCKTTRELML 70 80 90 100 110 120 HARCCLNQKG TILGLDLQNC SLEDPGPNFH QAHTTVIIDL QANPLKGDLA NTFRGFTQLQ 130 140 150 160 170 180 TLILPQHVNC PGGINAWNTI TSYIDNQICQ GQKNLCNNTG DPEMCPENGS CVPDGPGLLQ 190 200 210 220 CVCADGFHGY KCMRQGSFSL LMFFGILGAT TLSVSILLWA TQRRKAKTS

CATM prediction

The sequence of ARAID_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     200       210       220 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 SFSLLMFFGILGATTLSVSILLWATQR 7.2 -49.0° 2.8 32.1 -3.1
Model 2 SFSLLMFFGILGATTLSVSILLWATQR 7.4 -40.9° 0.6 43.0 -2.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 205, GLY, HA2 A, 204, PHE, O 3.49Å
B, 208, GLY, HA1 A, 205, GLY, O 3.29Å
A, 205, GLY, HA2 B, 204, PHE, O 3.49Å
A, 208, GLY, HA1 B, 205, GLY, O 3.29Å