Aminopeptidase Q {ECO:0000305}

UniProt data

UniProt name: AMPQ_HUMAN (Q6Q4G3)

Gene name: LVRN {ECO:0000312|HGNC:HGNC:26904}

Organism: Homo sapiens (Human).

Function: Metalloprotease which may be important for placentation by regulating biological activity of key peptides at the embryo- maternal interface. On synthetic substrates it shows a marked preference for Leu-4-methylcoumaryl-7-amide (Leu-MCA) over Met- MCA, Arg-LCA and Lys-LCA. Cleaves the N-terminal amino acid of several peptides such as angiotensin-3, kisspeptin-10 and endokinin C. {ECO:0000269|PubMed:17525158}.

Subcellular location: Membrane {ECO:0000303|PubMed:17525158}; Single-pass type II membrane protein {ECO:0000303|PubMed:17525158}.

Transmembrane domains:

  1. 14-34, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 990 AA

10 20 30 40 50 60 MGPPSSSGFY VSRAVALLLA GLVAALLLAL AVLAALYGHC ERVPPSELPG LRDLEAESSP 70 80 90 100 110 120 PLRQKPTPTP KPSSARELAV TTTPSNWRPP GPWDQLRLPP WLVPLHYDLE LWPQLRPDEL 130 140 150 160 170 180 PAGSLPFTGR VNITVRCTVA TSRLLLHSLF QDCERAEVRG PLSPGTGNAT VGRVPVDDVW 190 200 210 220 230 240 FALDTEYMVL ELSEPLKPGS SYELQLSFSG LVKEDLREGL FLNVYTDQGE RRALLASQLE 250 260 270 280 290 300 PTFARYVFPC FDEPALKATF NITMIHHPSY VALSNMPKLG QSEKEDVNGS KWTVTTFSTT 310 320 330 340 350 360 PHMPTYLVAF VICDYDHVNR TERGKEIRIW ARKDAIANGS ADFALNITGP IFSFLEDLFN 370 380 390 400 410 420 ISYSLPKTDI IALPSFDNHA MENWGLMIFD ESGLLLEPKD QLTEKKTLIS YVVSHEIGHQ 430 440 450 460 470 480 WFGNLVTMNW WNNIWLNEGF ASYFEFEVIN YFNPKLPRNE IFFSNILHNI LREDHALVTR 490 500 510 520 530 540 AVAMKVENFK TSEIQELFDI FTYSKGASMA RMLSCFLNEH LFVSALKSYL KTFSYSNAEQ 550 560 570 580 590 600 DDLWRHFQMA IDDQSTVILP ATIKNIMDSW THQSGFPVIT LNVSTGVMKQ EPFYLENIKN 610 620 630 640 650 660 RTLLTSNDTW IVPILWIKNG TTQPLVWLDQ SSKVFPEMQV SDSDHDWVIL NLNMTGYYRV 670 680 690 700 710 720 NYDKLGWKKL NQQLEKDPKA IPVIHRLQLI DDAFSLSKNN YIEIETALEL TKYLAEEDEI 730 740 750 760 770 780 IVWHTVLVNL VTRDLVSEVN IYDIYSLLKR YLLKRLNLIW NIYSTIIREN VLALQDDYLA 790 800 810 820 830 840 LISLEKLFVT ACWLGLEDCL QLSKELFAKW VDHPENEIPY PIKDVVLCYG IALGSDKEWD 850 860 870 880 890 900 ILLNTYTNTT NKEEKIQLAY AMSCSKDPWI LNRYMEYAIS TSPFTSNETN IIEVVASSEV 910 920 930 940 950 960 GRYVAKDFLV NNWQAVSKRY GTQSLINLIY TIGRTVTTDL QIVELQQFFS NMLEEHQRIR 970 980 VHANLQTIKN ENLKNKKLSA RIAAWLRRNT

CATM prediction

The sequence of AMPQ_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           20        30      
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 VSRAVALLLAGLVAALLLALAVLAALY 7.4 -47.1° 2.3 44.3 -17.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 18, LEU, HA A, 17, LEU, O 3.33Å
B, 21, GLY, HA1 A, 18, LEU, O 3.08Å
B, 22, LEU, HA A, 21, GLY, O 3.39Å
A, 18, LEU, HA B, 17, LEU, O 3.33Å
A, 21, GLY, HA1 B, 18, LEU, O 3.08Å
A, 22, LEU, HA B, 21, GLY, O 3.39Å