2-oxoglutarate and iron-dependent oxygenase domain-containing protein 3

UniProt data

UniProt name: OGFD3_HUMAN (Q6PK18)

Gene name: OGFOD3; Synonyms=C17orf101

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 43-65, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 319 AA

10 20 30 40 50 60 MAPQRRAATK APEGNGAAER RNRSSTKKDR APREVQRLWQ RPWLRTAGLG AGFVLTALLL 70 80 90 100 110 120 WSSLGADDGV AEVLARRGEV VAGRFIEVPC SEDYDSHRRF EGCTPRKCGR GVTDVVITRE 130 140 150 160 170 180 EAERIRSVAE KGLSLGGSDG GASILDLHSG ALSVGKHFVN LYRYFGDKIQ NIFSEEDFRL 190 200 210 220 230 240 YREVRQKVQL TIAEAFGISA SSLHLTKPTF FSRINSTEAR TAHDEYWHAH VDKVTYGSFD 250 260 270 280 290 300 YTSLLYLSNY LEDFGGGRFM FMEEGANKTV EPRAGRVSFF TSGSENLHRV EKVHWGTRYA 310 ITIAFSCNPD HGIEDPAFP

CATM prediction

The sequence of OGFD3_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  40        50        60       
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 QRAWLRTAGLGAGFVLTALLLWSSLGADD 6.8 -45.0° 5.6 44.8 -18.0
Model 2 QRAWLRTAGLGAGFVLTALLLWSSLGADD 7.4 -46.2° 3.6 37.0 -6.8
Prolines* QRPWLRTAGLGAGFVLTALLLWSSLGADD          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 48, GLY, HA1 A, 45, ARG, O 3.06Å
B, 49, LEU, HA A, 48, GLY, O 2.66Å
B, 52, GLY, HA1 A, 49, LEU, O 3.26Å
B, 53, PHE, HA A, 56, THR, OG1 3.33Å
A, 48, GLY, HA1 B, 45, ARG, O 3.06Å
A, 49, LEU, HA B, 48, GLY, O 2.66Å
A, 52, GLY, HA1 B, 49, LEU, O 3.26Å
A, 56, THR, HG1 B, 56, THR, OG1 2.47Å