Consortin

UniProt data

UniProt name: CNST_HUMAN (Q6PJW8)

Gene name: CNST; Synonyms=C1orf71

Organism: Homo sapiens (Human).

Function: Required for targeting of connexins to the plasma membrane. {ECO:0000269|PubMed:19864490}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:19864490}; Single-pass membrane protein {ECO:0000269|PubMed:19864490}. Golgi apparatus, trans-Golgi network membrane {ECO:0000269|PubMed:19864490}; Single-pass membrane protein {ECO:0000269|PubMed:19864490}. Cytoplasmic vesicle, secretory vesicle {ECO:0000269|PubMed:19864490}. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans- Golgi network and the cell membrane via the secretory pathway.

Transmembrane domains:

  1. 665-685, 21 AA, Helical. {ECO:0000255}.

Sequence: 725 AA

10 20 30 40 50 60 MDDSDTPTYY LQIEPQDGCH PGDSVERSVT CLPSASDENE NQLDGDGHEH LTSSDSAMGK 70 80 90 100 110 120 PQVSEQDSLN NNESCTLSCE VAAGENLQNT LCEASRDEQA FLGKDKKIPG KRSPRSKKGT 130 140 150 160 170 180 AKKIPPGLFS GDIAPLMQEK VLSAVTYAVD DEEAAEVNAN EQPEAPKLVL QSLFSLIRGE 190 200 210 220 230 240 VEQLDSRALP LCLHQIAESY FQEEDYEKAM KFIQLERLYH EQLLANLSAI QEQWETKWKT 250 260 270 280 290 300 VQPHTVTALR NSEKGFNGED FERLTKICAT HQDPLLSKHK IAAVEKSQER KCSTQLLVSE 310 320 330 340 350 360 DPKEGGATTK ESESKTCLGT ESSKESQHTV EPLGSSPCCH QMDVQTDSPS LSVTAGKDHM 370 380 390 400 410 420 EELLCSAEAT LALHTQSSET AGSPSGPDSS EDACEDDSRL QLAQTEACQD VARIEGIAED 430 440 450 460 470 480 PKVFLSSKSK TEPLISPGCD RIPPALISEG KYSQAQRKEL RLPLRDASEA LPTDQLENNE 490 500 510 520 530 540 LNELQQPDLT DSDGKSPQAQ ADSDGSENVL CGNNQISDLG ILLPEVCMAP EEKGDKDDQL 550 560 570 580 590 600 NKETEDYLNS LLEGCLKDTE DSLSYEDNQD DDSDLLQDLS PEEASYSLQE NLPSDESCLS 610 620 630 640 650 660 LDDLAKRIEI AEVVPTEGLV SILKKRNDTV GDHPAQMQHK PSKRRVRFQE IDDSLDQDEV 670 680 690 700 710 720 GGGSCILLVL LCIATVFLSV GGTALYCTFG DMESPVCTDF ADNMDFYYTK LLQGVAELKH WIYLS

CATM prediction

The sequence of CNST_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          670       680      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 GGSCILLVLLCIATVFLSVGGTALYCT 7.2 -52.7° 2.0 44.9 -5.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 679, SER, HA A, 678, LEU, O 3.44Å
B, 682, GLY, HA1 A, 679, SER, O 3.07Å
A, 679, SER, HA B, 678, LEU, O 3.44Å
A, 682, GLY, HA1 B, 679, SER, O 3.07Å