Leucine-rich repeat and fibronectin type-III domain-containing protein 4

UniProt data

UniProt name: LRFN4_HUMAN (Q6PJG9)

Gene name: LRFN4; Synonyms=SALM3

Organism: Homo sapiens (Human).

Function: Promotes neurite outgrowth in hippocampal neurons. May play a role in redistributing DLG4 to the cell periphery (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 519-539, 21 AA, Helical. {ECO:0000255}.

Sequence: 635 AA

10 20 30 40 50 60 MAPPLLLLLL ASGAAACPLP CVCQNLSESL STLCAHRGLL FVPPNVDRRT VELRLADNFI 70 80 90 100 110 120 QALGPPDFRN MTGLVDLTLS RNAITRIGAR AFGDLESLRS LHLDGNRLVE LGTGSLRGPV 130 140 150 160 170 180 NLQHLILSGN QLGRIAPGAF DDFLESLEDL DLSYNNLRQV PWAGIGAMPA LHTLNLDHNL 190 200 210 220 230 240 IDALPPGAFA QLGQLSRLDL TSNRLATLAP DPLFSRGRDA EASPAPLVLS FSGNPLHCNC 250 260 270 280 290 300 ELLWLRRLAR PDDLETCASP PGLAGRYFWA VPEGEFSCEP PLIARHTQRL WVLEGQRATL 310 320 330 340 350 360 RCRALGDPAP TMHWVGPDDR LVGNSSRARA FPNGTLEIGV TGAGDAGGYT CIATNPAGEA 370 380 390 400 410 420 TARVELRVLA LPHGGNSSAE GGRPGPSDIA ASARTAAEGE GTLESEPAVQ VTEVTATSGL 430 440 450 460 470 480 VSWGPGRPAD PVWMFQIQYN SSEDETLIYR IVPASSHHFL LKHLVPGADY DLCLLALSPA 490 500 510 520 530 540 AGPSDLTATR LLGCAHFSTL PASPLCHALQ AHVLGGTLTV AVGGVLVAAL LVFTVALLVR 550 560 570 580 590 600 GRGAGNGRLP LKLSHVQSQT NGGPSPTPKA HPPRSPPPRP QRSCSLDLGD AGCYGYARRL 610 620 630 GGAWARRSHS VHGGLLGAGC RGVGGSAERL EESVV

CATM prediction

The sequence of LRFN4_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      520       530       540
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 GTLTVAVGGVLVAALLVFTVALLVRGR 7.2 -44.0° 1.8 44.8 -17.8

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 521, ALA, HA A, 520, VAL, O 3.37Å
B, 524, GLY, HA1 A, 521, ALA, O 3.16Å
B, 525, VAL, HA A, 524, GLY, O 3.42Å
A, 521, ALA, HA B, 520, VAL, O 3.37Å
A, 524, GLY, HA1 B, 521, ALA, O 3.16Å
A, 525, VAL, HA B, 524, GLY, O 3.42Å