Iodotyrosine deiodinase 1 {ECO:0000303|Ref.2}

UniProt data

UniProt name: IYD1_HUMAN (Q6PHW0)

Gene name: IYD; Synonyms=C6orf71, DEHAL1

Organism: Homo sapiens (Human).

Function: Catalyzes the oxidative NADPH-dependent deiodination of monoiodotyrosine (L-MIT) or diiodotyrosine (L-DIT). Acts during the hydrolysis of thyroglobulin to liberate iodide, which can then reenter the hormone-producing pathways. Acts more efficiently on monoiodotyrosine than on diiodotyrosine. {ECO:0000269|PubMed:15289438}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:15289438}; Single-pass membrane protein {ECO:0000269|PubMed:15289438}.

Transmembrane domains:

  1. 215-235, 21 AA, Helical. {ECO:0000255}.

Sequence: 289 AA

10 20 30 40 50 60 MYFLTPILVA ILCILVVWIF KNADRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED 70 80 90 100 110 120 ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI 130 140 150 160 170 180 RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW 190 200 210 220 230 240 IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNEISVSIA CGILLAALQN AGLVTVTTTP 250 260 270 280 LNCGPRLRVL LGRPAHEKLL MLLPVGYPSK EATVPDLKRK PLDQIMVTV

CATM prediction

The sequence of IYD1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
          220       230      
   +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 YNEISVSIACGILLAALQNAGLVTVTT 7.1 -43.9° 1.8 45.0 -19.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 219, ILE, HA A, 218, SER, O 3.31Å
B, 222, GLY, HA1 A, 219, ILE, O 3.09Å
B, 223, ILE, HA A, 222, GLY, O 3.37Å
A, 219, ILE, HA B, 218, SER, O 3.31Å
A, 222, GLY, HA1 B, 219, ILE, O 3.09Å
A, 223, ILE, HA B, 222, GLY, O 3.37Å