Polypeptide N-acetylgalactosaminyltransferase 18

UniProt data

UniProt name: GLT18_HUMAN (Q6P9A2)

Gene name: GALNT18; Synonyms=GALNTL4

Organism: Homo sapiens (Human).

Function: Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. {ECO:0000269|PubMed:22186971}.

Subcellular location: Golgi apparatus membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 13-35, 23 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 607 AA

10 20 30 40 50 60 MVCTRKTKTL VSTCVILSGM TNIICLLYVG WVTNYIASVY VRGQEPAPDK KLEEDKGDTL 70 80 90 100 110 120 KIIERLDHLE NVIKQHIQEA PAKPEEAEAE PFTDSSLFAH WGQELSPEGR RVALKQFQYY 130 140 150 160 170 180 GYNAYLSDRL PLDRPLPDLR PSGCRNLSFP DSLPEVSIVF IFVNEALSVL LRSIHSAMER 190 200 210 220 230 240 TPPHLLKEII LVDDNSSNEE LKEKLTEYVD KVNSQKPGFI KVVRHSKQEG LIRSRVSGWR 250 260 270 280 290 300 AATAPVVALF DAHVEFNVGW AEPVLTRIKE NRKRIISPSF DNIKYDNFEI EEYPLAAQGF 310 320 330 340 350 360 DWELWCRYLN PPKAWWKLEN STAPIRSPAL IGCFIVDRQY FQEIGLLDEG MEVYGGENVE 370 380 390 400 410 420 LGIRVWQCGG SVEVLPCSRI AHIERAHKPY TEDLTAHVRR NALRVAEVWM DEFKSHVYMA 430 440 450 460 470 480 WNIPQEDSGI DIGDITARKA LRKQLQCKTF RWYLVSVYPE MRMYSDIIAY GVLQNSLKTD 490 500 510 520 530 540 LCLDQGPDTE NVPIMYICHG MTPQNVYYTS SQQIHVGILS PTVDDDDNRC LVDVNSRPRL 550 560 570 580 590 600 IECSYAKAKR MKLHWQFSQG GPIQNRKSKR CLELQENSDL EFGFQLVLQK CSGQHWSITN VLRSLAS

CATM prediction

The sequence of GLT18_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  10        20        30       
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 LVSTCVILSGMTNIICLLYVGWVTNYIAS 7.2 -51.1° 1.2 44.7 -12.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 30, GLY, HA1 A, 27, LEU, O 3.49Å
B, 34, ASN, HD21 A, 34, ASN, OD1 1.87Å
B, 35, TYR, HA A, 34, ASN, OD1 3.44Å
A, 30, GLY, HA1 B, 27, LEU, O 3.49Å