UniProt data
UniProt name: TMM81_HUMAN (Q6P7N7)
Gene name: TMEM81; ORFNames=UNQ2788/PRO7178
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 227-247, 21 AA, Helical. {ECO:0000255}.
Sequence: 255 AA
10 20 30 40 50 60
MKVLATSFVL GSLGLAFYLP LVVTTPKTLA IPEKLQEAVG KVIINATTCT VTCGLGYKEE
70 80 90 100 110 120
TVCEVGPDGV RRKCQTRRLE CLTNWICGML HFTILIGKEF ELSCLSSDIL EFGQEAFRFT
130 140 150 160 170 180
WRLARGVIST DDEVFKPFQA NSHFVKFKYA QEYDSGTYRC DVQLVKNLRL VKRLYFGLRV
190 200 210 220 230 240
LPPNLVNLNF HQSLTEDQKL IDEGLEVNLD SYSKPHHPKW KKKVASALGI GIAIGVVGGV
250
LVRIVLCALR GGLQQ
CATM prediction
The sequence of TMM81_HUMAN returned 8 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 230 240 2 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | VASALGIGIAIGVVGGVLVRIVLCALR | 6.4 | -38.0° | 4.5 | 57.4 | -55.0 |
| Model 2 | VASALGIGIAIGVVGGVLVRIVLCALR | 6.9 | -55.0° | 0.9 | 50.1 | -35.3 |
| Model 3 | VASALGIGIAIGVVGGVLVRIVLCALR | 6.9 | -31.9° | 1.2 | 57.9 | -28.9 |
| Model 4 | VASALGIGIAIGVVGGVLVRIVLCALR | 6.5 | -47.9° | 0.8 | 53.9 | -28.7 |
| Model 5 | VASALGIGIAIGVVGGVLVRIVLCALR | 7.1 | -53.2° | 3.1 | 34.3 | -24.4 |
| Model 6 | VASALGIGIAIGVVGGVLVRIVLCALR | 6.7 | -52.0° | 1.4 | 56.9 | -22.7 |
| Model 7 | VASALGIGIAIGVVGGVLVRIVLCALR | 7.0 | -27.0° | 4.2 | 52.3 | -19.2 |
| Model 8 | VASALGIGIAIGVVGGVLVRIVLCALR | 6.7 | -51.0° | 3.3 | 48.1 | -8.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 228, LEU, HA | A, 227, ALA, O | 3.18Å |
| B, 231, GLY, HA1 | A, 228, LEU, O | 2.80Å |
| B, 232, ILE, HA | A, 231, GLY, O | 2.29Å |
| B, 235, GLY, HA1 | A, 232, ILE, O | 2.96Å |
| A, 228, LEU, HA | B, 227, ALA, O | 3.18Å |
| A, 231, GLY, HA1 | B, 228, LEU, O | 2.80Å |
| A, 232, ILE, HA | B, 231, GLY, O | 2.29Å |
| A, 235, GLY, HA1 | B, 232, ILE, O | 2.96Å |
