UniProt data
UniProt name: F173B_HUMAN (Q6P4H8)
Gene name: FAM173B
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 38-58, 21 AA, Helical. {ECO:0000255}.
Sequence: 233 AA
10 20 30 40 50 60
MEGGGGIPLE TLKEESQSRH VLPASFEVNS LQKSNWGFLL TGLVGGTLVA VYAVATPFVT
70 80 90 100 110 120
PALRKVCLPF VPATTKQIEN VVKMLRCRRG SLVDIGSGDG RIVIAAAKKG FTAVGYELNP
130 140 150 160 170 180
WLVWYSRYRA WREGVHGSAK FYISDLWKVT FSQYSNVVIF GVPQMMLQLE KKLERELEDD
190 200 210 220 230
ARVIACRFPF PHWTPDHVTG EGIDTVWAYD ASTFRGREKR PCTSMHFQLP IQA
CATM prediction
The sequence of F173B_HUMAN returned 6 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 40 50 60 + | + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | NWGFLLTGLVGGTLVAVYAVATAFVTA | 6.5 | -38.8° | 1.0 | 43.1 | -44.9 |
| Model 2 | NWGFLLTGLVGGTLVAVYAVATAFVTA | 7.2 | -23.1° | 2.4 | 45.9 | -31.7 |
| Model 3 | NWGFLLTGLVGGTLVAVYAVATAFVTA | 6.6 | -53.8° | 2.8 | 51.2 | -30.3 |
| Model 4 | NWGFLLTGLVGGTLVAVYAVATAFVTA | 6.9 | -46.0° | 2.2 | 32.0 | -24.1 |
| Model 5 | NWGFLLTGLVGGTLVAVYAVATAFVTA | 6.6 | -54.9° | 0.9 | 50.0 | -20.1 |
| Model 6 | NWGFLLTGLVGGTLVAVYAVATAFVTA | 7.1 | +52.4° | 1.8 | 1.1 | -5.7 |
| Prolines* | NWGFLLTGLVGGTLVAVYAVATPFVTP |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 39, LEU, HA | A, 38, PHE, O | 2.88Å |
| B, 42, GLY, HA1 | A, 39, LEU, O | 2.57Å |
| B, 43, LEU, HA | A, 42, GLY, O | 2.52Å |
| B, 46, GLY, HA1 | A, 43, LEU, O | 3.35Å |
| A, 39, LEU, HA | B, 38, PHE, O | 2.88Å |
| A, 42, GLY, HA1 | B, 39, LEU, O | 2.57Å |
| A, 43, LEU, HA | B, 42, GLY, O | 2.52Å |
| A, 46, GLY, HA1 | B, 43, LEU, O | 3.35Å |
