UDP-glucuronosyltransferase 3A1

UniProt data

UniProt name: UD3A1_HUMAN (Q6NUS8)

Gene name: UGT3A1

Organism: Homo sapiens (Human).

Function: UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 484-504, 21 AA, Helical. {ECO:0000255}.

Sequence: 523 AA

10 20 30 40 50 60 MVGQRVLLLV AFLLSGVLLS EAAKILTIST LGGSHYLLLD RVSQILQEHG HNVTMLHQSG 70 80 90 100 110 120 KFLIPDIKEE EKSYQVIRWF SPEDHQKRIK KHFDSYIETA LDGRKESEAL VKLMEIFGTQ 130 140 150 160 170 180 CSYLLSRKDI MDSLKNENYD LVFVEAFDFC SFLIAEKLVK PFVAILPTTF GSLDFGLPSP 190 200 210 220 230 240 LSYVPVFPSL LTDHMDFWGR VKNFLMFFSF SRSQWDMQST FDNTIKEHFP EGSRPVLSHL 250 260 270 280 290 300 LLKAELWFVN SDFAFDFARP LLPNTVYIGG LMEKPIKPVP QDLDNFIANF GDAGFVLVAF 310 320 330 340 350 360 GSMLNTHQSQ EVLKKMHNAF AHLPQGVIWT CQSSHWPRDV HLATNVKIVD WLPQSDLLAH 370 380 390 400 410 420 PSIRLFVTHG GQNSVMEAIR HGVPMVGLPV NGDQHGNMVR VVAKNYGVSI RLNQVTADTL 430 440 450 460 470 480 TLTMKQVIED KRYKSAVVAA SVILHSQPLS PAQRLVGWID HILQTGGATH LKPYAFQQPW 490 500 510 520 HEQYLIDVFV FLLGLTLGTM WLCGKLLGVV ARWLRGARKV KKT

CATM prediction

The sequence of UD3A1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           490       500     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 HEQYLIDVFVFLLGLTLGTMWLCGKLL 7.4 -45.8° 2.7 47.1 -6.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 491, PHE, HA A, 490, VAL, O 3.40Å
B, 494, GLY, HA1 A, 491, PHE, O 3.39Å
A, 491, PHE, HA B, 490, VAL, O 3.40Å
A, 494, GLY, HA1 B, 491, PHE, O 3.39Å