Uncharacterized family 31 glucosidase KIAA1161

UniProt data

UniProt name: K1161_HUMAN (Q6NSJ0)

Gene name: KIAA1161

Organism: Homo sapiens (Human).

Function: Putative glucosidase. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 57-77, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 714 AA

10 20 30 40 50 60 MLQNPQEKSQ AYPRRRRPGC YAYRQNPEAI AAAAMYTFLP DNFSPAKPKP SKDLKPLLGS 70 80 90 100 110 120 AVLGLLLVLA AVVAWCYYSV SLRKAERLRA ELLDLKAGGF SIRNQKGEQV FRLAFRSGAL 130 140 150 160 170 180 DLDSCSRDGA LLGCSLTADG LPLHFFIQTV RPKDTVMCYR VRWEEAAPGR AVEHAMFLGD 190 200 210 220 230 240 AAAHWYGGAE MRTQHWPIRL DGQQEPQPFV TSDVYSSDAA FGGILERYWL SSRAAAIKVN 250 260 270 280 290 300 DSVPFHLGWN STERSLRLQA RYHDTPYKPP AGRAAAPELS YRVCVGSDVT SIHKYMVRRY 310 320 330 340 350 360 FNKPSRVPAP EAFRDPIWST WALYGRAVDQ DKVLRFAQQI RLHHFNSSHL EIDDMYTPAY 370 380 390 400 410 420 GDFDFDEVKF PNASDMFRRL RDAGFRVTLW VHPFVNYNSS RFGEGVEREL FVREPTGRLP 430 440 450 460 470 480 ALVRWWNGIG AVLDFTHPKA RDWFQGHLRR LRSRYSVASF KFDAGEVSYL PRDFSTYRPL 490 500 510 520 530 540 PDPSVWSRRY TEMALPFFSL AEVRVGYQSQ NISCFFRLVD RDSVWGYDLG LRSLIPAVLT 550 560 570 580 590 600 VSMLGYPFIL PDMVGGNAVP QRTAGGDVPE RELYIRWLEV AAFMPAMQFS IPPWRYDAEV 610 620 630 640 650 660 VAIAQKFAAL RASLVAPLLL ELAGEVTDTG DPIVRPLWWI APGDETAHRI DSQFLIGDTL 670 680 690 700 710 LVAPVLEPGK QERDVYLPAG KWRSYKGELF DKTPVLLTDY PVDLDEIAYF TWAS

CATM prediction

The sequence of K1161_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        60        70        8
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 LKALLGSAVLGLLLVLAAVVAWCYYSV 6.6 -49.0° 3.9 38.0 -7.4
Model 2 LKALLGSAVLGLLLVLAAVVAWCYYSV 7.4 -53.8° 3.6 48.9 -3.7
Prolines* LKPLLGSAVLGLLLVLAAVVAWCYYSV          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session