Tyrosine-protein kinase STYK1

UniProt data

UniProt name: STYK1_HUMAN (Q6J9G0)

Gene name: STYK1; Synonyms=NOK

Organism: Homo sapiens (Human).

Function: Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 26-46, 21 AA, Helical. {ECO:0000255}.

Sequence: 422 AA

10 20 30 40 50 60 MGMTRMLLEC SLSDKLCVIQ EKQYEVIIVP TLLVTIFLIL LGVILWLFIR EQRTQQQRSG 70 80 90 100 110 120 PQGIAPVPPP RDLSWEAGHG GNVALPLKET SVENFLGATT PALAKLQVPR EQLSEVLEQI 130 140 150 160 170 180 CSGSCGPIFR ANMNTGDPSK PKSVILKALK EPAGLHEVQD FLGRIQFHQY LGKHKNLVQL 190 200 210 220 230 240 EGCCTEKLPL YMVLEDVAQG DLLSFLWTCR RDVMTMDGLL YDLTEKQVYH IGKQVLLALE 250 260 270 280 290 300 FLQEKHLFHG DVAARNILMQ SDLTAKLCGL GLAYEVYTRG AISSTQTIPL KWLAPERLLL 310 320 330 340 350 360 RPASIRADVW SFGILLYEMV TLGAPPYPEV PPTSILEHLQ RRKIMKRPSS CTHTMYSIMK 370 380 390 400 410 420 SCWRWREADR PSPRELRLRL EAAIKTADDE AVLQVPELVV PELYAAVAGI RVESLFYNYS ML

CATM prediction

The sequence of STYK1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         30        40        
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 QYEVIIVATLLVTIFLILLGVILWLFI 7.3 -55.0° 2.4 47.8 -2.5
Prolines* QYEVIIVPTLLVTIFLILLGVILWLFI          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 39, ILE, HA A, 38, LEU, O 3.49Å
B, 42, GLY, HA1 A, 39, ILE, O 3.24Å
A, 39, ILE, HA B, 38, LEU, O 3.49Å
A, 42, GLY, HA1 B, 39, ILE, O 3.24Å