Dehydrogenase/reductase SDR family member 7B

UniProt data

UniProt name: DRS7B_HUMAN (Q6IAN0)

Gene name: DHRS7B; Synonyms=SDR32C1 {ECO:0000303|PubMed:19027726}

Organism: Homo sapiens (Human).

Function: Putative oxidoreductase. {ECO:0000305}.

Subcellular location: Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 18-38, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 325 AA

10 20 30 40 50 60 MVSPATRKSL PKVKAMDFIT STAILPLLFG CLGVFGLFRL LQWVRGKAYL RNAVVVITGA 70 80 90 100 110 120 TSGLGKECAK VFYAAGAKLV LCGRNGGALE ELIRELTASH ATKVQTHKPY LVTFDLTDSG 130 140 150 160 170 180 AIVAAAAEIL QCFGYVDILV NNAGISYRGT IMDTTVDVDK RVMETNYFGP VALTKALLPS 190 200 210 220 230 240 MIKRRQGHIV AISSIQGKMS IPFRSAYAAS KHATQAFFDC LRAEMEQYEI EVTVISPGYI 250 260 270 280 290 300 HTNLSVNAIT ADGSRYGVMD TTTAQGRSPV EVAQDVLAAV GKKKKDVILA DLLPSLAVYL 310 320 RTLAPGLFFS LMASRARKER KSKNS

CATM prediction

The sequence of DRS7B_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
       20        30        40
+    |    +    |    +    | 		 (Å) (°) (Å) (°)  
Model 1 AMDFITSTAILALLFGCLGVFGLFRLL 7.3 -43.1° 4.5 35.1 -12.6
Model 2 AMDFITSTAILALLFGCLGVFGLFRLL 7.0 +48.0° 2.0 -0.2 -12.1
Model 3 AMDFITSTAILALLFGCLGVFGLFRLL 7.1 +52.0° 1.8 1.0 -9.7
Prolines* AMDFITSTAILPLLFGCLGVFGLFRLL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 27, LEU, HA A, 26, ALA, O 3.21Å
B, 30, GLY, HA1 A, 27, LEU, O 3.37Å
A, 27, LEU, HA B, 26, ALA, O 3.21Å
A, 30, GLY, HA1 B, 27, LEU, O 3.37Å