Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

UniProt data

UniProt name: IPIL1_HUMAN (Q6GPH6)

Gene name: ITPRIPL1; Synonyms=KIAA1754L

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 104-124, 21 AA, Helical. {ECO:0000255}.

Sequence: 555 AA

10 20 30 40 50 60 MNVDAEASMA VISLLFLAVM YVVHHPLMVS DRMDLDTLAR SRQLEKRMSE EMRLLEMEFE 70 80 90 100 110 120 ERKRAAEQRQ KAENFWTGDT SSDQLVLGKK DMGWPFQADG QEGPLGWMLG NLWNTGLFCL 130 140 150 160 170 180 FLVFELLRQN MQHEPAFDSS SEEEEEEVRV VPVTSYNWLT DFPSQEALDS FYKHYVQNAI 190 200 210 220 230 240 RDLPCTCEFV ESFVDDLIEA CRVLSRQEAH PQLEDCLGIG AAFEKWGTLH ETQKFDILVP 250 260 270 280 290 300 IVPPQGTMFV LEMRDPALGR RCGCVLVESE CVCKREKLLG DVLCLVHHHR DPSAVLGKCS 310 320 330 340 350 360 SSIKAALCTG FHLDVCKTVQ WFRNMMGNAW ALVAHKYDFK LSLPPSTTSC KLRLDYRSGR 370 380 390 400 410 420 FLSIHLVLGV QREDTLVYLV SQAPDQEQLT SVDWPESFVA CEHLFLKLVG RFAPENTCHL 430 440 450 460 470 480 KCLQIILSLR QHQSLPHGAS RPILTSYHFK TALMHLLLRL PLTDWAHNML SQRLQDILWF 490 500 510 520 530 540 LGRGLQQRSL HHFLIGNNFL PLTIPIPKTF RNAEPVNLFQ HLVLNPKAHS QAVEEFQNLL 550 TQVKTLPHAP LAAAP

CATM prediction

The sequence of IPIL1_HUMAN returned 5 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
           110       120     
    +    |    +    |    +  		 (Å) (°) (Å) (°)  
Model 1 QEGALGWMLGNLWNTGLFCLFLVFELL 6.9 -23.0° 4.2 54.0 -42.7
Model 2 QEGALGWMLGNLWNTGLFCLFLVFELL 6.6 -41.7° 1.3 45.1 -36.3
Model 3 QEGALGWMLGNLWNTGLFCLFLVFELL 7.0 -51.1° 2.4 44.9 -28.5
Model 4 QEGALGWMLGNLWNTGLFCLFLVFELL 7.0 -48.0° 4.3 35.0 -18.7
Model 5 QEGALGWMLGNLWNTGLFCLFLVFELL 6.8 +38.0° 4.0 77.0 -16.2
Prolines* QEGPLGWMLGNLWNTGLFCLFLVFELL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 114, ASN, HA A, 114, ASN, OD1 2.91Å
A, 114, ASN, HA B, 114, ASN, OD1 2.89Å