Fatty-acid amide hydrolase 2

UniProt data

UniProt name: FAAH2_HUMAN (Q6GMR7)

Gene name: FAAH2; Synonyms=AMDD

Organism: Homo sapiens (Human).

Function: Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes monounsaturated substrate anandamide preferentially as compared to polyunsaturated substrates. {ECO:0000269|PubMed:17015445}.

Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 11-31, 21 AA, Helical. {ECO:0000255}.

Sequence: 532 AA

10 20 30 40 50 60 MAPSFTARIQ LFLLRALGFL IGLVGRAALV LGGPKFASKT PRPVTEPLLL LSGMQLAKLI 70 80 90 100 110 120 RQRKVKCIDV VQAYINRIKD VNPMINGIVK YRFEEAMKEA HAVDQKLAEK QEDEATLENK 130 140 150 160 170 180 WPFLGVPLTV KEAFQLQGMP NSSGLMNRRD AIAKTDATVV ALLKGAGAIP LGITNCSELC 190 200 210 220 230 240 MWYESSNKIY GRSNNPYDLQ HIVGGSSGGE GCTLAAACSV IGVGSDIGGS IRMPAFFNGI 250 260 270 280 290 300 FGHKPSPGVV PNKGQFPLAV GAQELFLCTG PMCRYAEDLA PMLKVMAGPG IKRLKLDTKV 310 320 330 340 350 360 HLKDLKFYWM EHDGGSFLMS KVDQDLIMTQ KKVVVHLETI LGASVQHVKL KKMKYSFQLW 370 380 390 400 410 420 IAMMSAKGHD GKEPVKFVDL LGDHGKHVSP LWELIKWCLG LSVYTIPSIG LALLEEKLRY 430 440 450 460 470 480 SNEKYQKFKA VEESLRKELV DMLGDDGVFL YPSHPTVAPK HHVPLTRPFN FAYTGVFSAL 490 500 510 520 530 GLPVTQCPLG LNAKGLPLGI QVVAGPFNDH LTLAVAQYLE KTFGGWVCPG KF

CATM prediction

The sequence of FAAH2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    10        20        30   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 RIQLFLLRALGFLIGLVGRAALVLGGA 6.5 +54.0° 3.3 80.0 -16.1
Prolines* RIQLFLLRALGFLIGLVGRAALVLGGP          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 19, PHE, HA A, 18, GLY, O 3.01Å
B, 22, GLY, HA1 A, 18, GLY, O 3.05Å
B, 22, GLY, HA2 A, 21, ILE, O 3.35Å
A, 19, PHE, HA B, 18, GLY, O 3.01Å
A, 22, GLY, HA1 B, 18, GLY, O 3.05Å
A, 22, GLY, HA2 B, 21, ILE, O 3.35Å