C-type lectin domain family 6 member A

UniProt data

UniProt name: CLC6A_HUMAN (Q6EIG7)

Gene name: CLEC6A; Synonyms=CLECSF10, DECTIN2

Organism: Homo sapiens (Human).

Function: Binds high-mannose carbohydrates in a Ca(2+)-dependent manner. Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9- NF-kappa-B-dependent pathway (By similarity). {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 21-41, 21 AA, Helical; Signal-anchor for type II membrane protein. {ECO:0000255}.

Sequence: 209 AA

10 20 30 40 50 60 MMQEQQPQST EKRGWLSLRL WSVAGISIAL LSACFIVSCV VTYHFTYGET GKRLSELHSY 70 80 90 100 110 120 HSSLTCFSEG TKVPAWGCCP ASWKSFGSSC YFISSEEKVW SKSEQNCVEM GAHLVVFNTE 130 140 150 160 170 180 AEQNFIVQQL NESFSYFLGL SDPQGNNNWQ WIDKTPYEKN VRFWHLGEPN HSAEQCASIV 190 200 FWKPTGWGWN DVICETRRNS ICEMNKIYL

CATM prediction

The sequence of CLC6A_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
    20        30        40   
  |    +    |    +    |    		 (Å) (°) (Å) (°)  
Model 1 LRLWSVAGISIALLSACFIVSCVVTYH 7.2 -47.0° 1.3 45.1 -16.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 25, GLY, HA1 A, 22, SER, O 3.20Å
B, 26, ILE, HA A, 25, GLY, O 3.35Å
A, 25, GLY, HA1 B, 22, SER, O 3.20Å
A, 26, ILE, HA B, 25, GLY, O 3.35Å