CD276 antigen

UniProt data

UniProt name: CD276_HUMAN (Q5ZPR3)

Gene name: CD276; Synonyms=B7H3; ORFNames=PSEC0249, UNQ309/PRO352

Organism: Homo sapiens (Human).

Function: May participate in the regulation of T-cell-mediated immune response. May play a protective role in tumor cells by inhibiting natural-killer mediated cell lysis as well as a role of marker for detection of neuroblastoma cells. May be involved in the development of acute and chronic transplant rejection and in the regulation of lymphocytic activity at mucosal surfaces. Could also play a key role in providing the placenta and fetus with a suitable immunological environment throughout pregnancy. Both isoform 1 and isoform 2 appear to be redundant in their ability to modulate CD4 T-cell responses. Isoform 2 is shown to enhance the induction of cytotoxic T-cells and selectively stimulates interferon gamma production in the presence of T-cell receptor signaling. {ECO:0000269|PubMed:11224528, ECO:0000269|PubMed:12906861, ECO:0000269|PubMed:14764704, ECO:0000269|PubMed:15314238, ECO:0000269|PubMed:15682454, ECO:0000269|PubMed:15961727}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 467-487, 21 AA, Helical. {ECO:0000255}.

Sequence: 534 AA

10 20 30 40 50 60 MLRRRGSPGM GVHVGAALGA LWFCLTGALE VQVPEDPVVA LVGTDATLCC SFSPEPGFSL 70 80 90 100 110 120 AQLNLIWQLT DTKQLVHSFA EGQDQGSAYA NRTALFPDLL AQGNASLRLQ RVRVADEGSF 130 140 150 160 170 180 TCFVSIRDFG SAAVSLQVAA PYSKPSMTLE PNKDLRPGDT VTITCSSYQG YPEAEVFWQD 190 200 210 220 230 240 GQGVPLTGNV TTSQMANEQG LFDVHSILRV VLGANGTYSC LVRNPVLQQD AHSSVTITPQ 250 260 270 280 290 300 RSPTGAVEVQ VPEDPVVALV GTDATLRCSF SPEPGFSLAQ LNLIWQLTDT KQLVHSFTEG 310 320 330 340 350 360 RDQGSAYANR TALFPDLLAQ GNASLRLQRV RVADEGSFTC FVSIRDFGSA AVSLQVAAPY 370 380 390 400 410 420 SKPSMTLEPN KDLRPGDTVT ITCSSYRGYP EAEVFWQDGQ GVPLTGNVTT SQMANEQGLF 430 440 450 460 470 480 DVHSVLRVVL GANGTYSCLV RNPVLQQDAH GSVTITGQPM TFPPEALWVT VGLSVCLIAL 490 500 510 520 530 LVALAFVCWR KIKQSCEEEN AGAEDQDGEG EGSKTALQPL KHSDSKEDDG QEIA

CATM prediction

The sequence of CD276_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        470       480       4
 +    |    +    |    +    |		 (Å) (°) (Å) (°)  
Model 1 AEALWVTVGLSVCLIALLVALAFVCWR 7.2 -51.1° 2.4 45.0 -10.0
Prolines* PEALWVTVGLSVCLIALLVALAFVCWR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 469, VAL, HA A, 468, TRP, O 3.37Å
B, 472, GLY, HA1 A, 469, VAL, O 3.17Å
A, 469, VAL, HA B, 468, TRP, O 3.37Å
A, 472, GLY, HA1 B, 469, VAL, O 3.17Å