UniProt data
UniProt name: MIC13_HUMAN (Q5XKP0)
Gene name: MIC13 {ECO:0000303|PubMed:25997101}
Organism: Homo sapiens (Human).
Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Constituent of mature MICOS complex, it is required for the formation of cristae junction (CJ) and maintenance of cristae morphology. Required for the incorporation of MINOS1/MIC10 into the MICOS complex. {ECO:0000269|PubMed:25997101}.
Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:25997101}; Single-pass membrane protein {ECO:0000255}. Note=Enriched at crista junctions. {ECO:0000269|PubMed:25997101}.
Transmembrane domains:
- 8-26, 19 AA, Helical. {ECO:0000255}.
Sequence: 118 AA
CATM prediction
The sequence of MIC13_HUMAN returned 2 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 10 20 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | VWSLMRFLIKGSVAGGAVYLVYDQE | 7.0 | -42.9° | 0.0 | 33.9 | -25.2 |
| Model 2 | VWSLMRFLIKGSVAGGAVYLVYDQE | 6.9 | -55.0° | 1.5 | 44.9 | -4.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 15, GLY, HA1 | A, 12, LEU, O | 3.29Å |
| B, 16, SER, HA | A, 15, GLY, O | 2.87Å |
| B, 19, GLY, HA1 | A, 16, SER, O | 3.22Å |
| B, 24, LEU, HA | A, 23, TYR, OH | 3.04Å |
| A, 15, GLY, HA1 | B, 12, LEU, O | 3.29Å |
| A, 16, SER, HA | B, 15, GLY, O | 2.87Å |
| A, 19, GLY, HA1 | B, 16, SER, O | 3.22Å |
| A, 20, GLY, HA1 | B, 23, TYR, OH | 3.14Å |
