Platelet endothelial aggregation receptor 1

UniProt data

UniProt name: PEAR1_HUMAN (Q5VY43)

Gene name: PEAR1; Synonyms=MEGF12

Organism: Homo sapiens (Human).

Function: When overexpressed, reduces the number of both early and late non-adherent myeloid progenitor cells. {ECO:0000250}.

Subcellular location: Cell membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. Note=Detected on the cell surface in resting platelets. {ECO:0000269|PubMed:15851471}.

Transmembrane domains:

  1. 756-776, 21 AA, Helical. {ECO:0000255}.

Sequence: 1037 AA

10 20 30 40 50 60 MSPPLCPLLL LAVGLRLAGT LNPSDPNTCS FWESFTTTTK ESHSRPFSLL PSEPCERPWE 70 80 90 100 110 120 GPHTCPQPTV VYRTVYRQVV KTDHRQRLQC CHGFYESRGF CVPLCAQECV HGRCVAPNQC 130 140 150 160 170 180 QCVPGWRGDD CSSECAPGMW GPQCDKPCSC GNNSSCDPKS GVCSCPSGLQ PPNCLQPCTP 190 200 210 220 230 240 GYYGPACQFR CQCHGAPCDP QTGACFCPAE RTGPSCDVSC SQGTSGFFCP STHSCQNGGV 250 260 270 280 290 300 FQTPQGSCSC PPGWMGTICS LPCPEGFHGP NCSQECRCHN GGLCDRFTGQ CRCAPGYTGD 310 320 330 340 350 360 RCREECPVGR FGQDCAETCD CAPDARCFPA NGACLCEHGF TGDRCTDRLC PDGFYGLSCQ 370 380 390 400 410 420 APCTCDREHS LSCHPMNGEC SCLPGWAGLH CNESCPQDTH GPGCQEHCLC LHGGVCQATS 430 440 450 460 470 480 GLCQCAPGYT GPHCASLCPP DTYGVNCSAR CSCENAIACS PIDGECVCKE GWQRGNCSVP 490 500 510 520 530 540 CPPGTWGFSC NASCQCAHEA VCSPQTGACT CTPGWHGAHC QLPCPKGQFG EGCASRCDCD 550 560 570 580 590 600 HSDGCDPVHG RCQCQAGWMG ARCHLSCPEG LWGVNCSNTC TCKNGGTCLP ENGNCVCAPG 610 620 630 640 650 660 FRGPSCQRSC QPGRYGKRCV PCKCANHSFC HPSNGTCYCL AGWTGPDCSQ PCPPGHWGEN 670 680 690 700 710 720 CAQTCQCHHG GTCHPQDGSC ICPLGWTGHH CLEGCPLGTF GANCSQPCQC GPGEKCHPET 730 740 750 760 770 780 GACVCPPGHS GAPCRIGIQE PFTVMPTTPV AYNSLGAVIG IAVLGSLVVA LVALFIGYRH 790 800 810 820 830 840 WQKGKEHHHL AVAYSSGRLD GSEYVMPDVP PSYSHYYSNP SYHTLSQCSP NPPPPNKVPG 850 860 870 880 890 900 PLFASLQNPE RPGGAQGHDN HTTLPADWKH RREPPPGPLD RGSSRLDRSY SYSYSNGPGP 910 920 930 940 950 960 FYNKGLISEE ELGASVASLS SENPYATIRD LPSLPGGPRE SSYMEMKGPP SGSPPRQPPQ 970 980 990 1000 1010 1020 FWDSQRRRQP QPQRDSGTYE QPSPLIHDRD SVGSQPPLPP GLPPGHYDSP KNSHIPGHYD 1030 LPPVRHPPSP PLRRQDR

CATM prediction

The sequence of PEAR1_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         760       770       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 NSLGAVIGIAVLGSLVVALVALFIGYR 6.5 -55.0° 5.5 40.2 -12.4

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 757, ALA, HA A, 756, GLY, O 2.51Å
B, 757, ALA, HA A, 757, ALA, O 3.50Å
B, 760, GLY, HA1 A, 757, ALA, O 3.13Å
A, 757, ALA, HA B, 756, GLY, O 2.51Å
A, 757, ALA, HA B, 757, ALA, O 3.50Å
A, 760, GLY, HA1 B, 757, ALA, O 3.13Å