Interleukin-23 receptor

UniProt data

UniProt name: IL23R_HUMAN (Q5VWK5)

Gene name: IL23R

Organism: Homo sapiens (Human).

Function: Associates with IL12RB1 to form the interleukin-23 receptor. Binds IL23 and mediates T-cells, NK cells and possibly certain macrophage/myeloid cells stimulation probably through activation of the Jak-Stat signaling cascade. IL23 functions in innate and adaptive immunity and may participate in acute response to infection in peripheral tissues. IL23 may be responsible for autoimmune inflammatory diseases and be important for tumorigenesis. {ECO:0000269|PubMed:12023369}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:12023369}; Single-pass type I membrane protein {ECO:0000269|PubMed:12023369}.

Transmembrane domains:

  1. 356-376, 21 AA, Helical. {ECO:0000255}.

Sequence: 629 AA

10 20 30 40 50 60 MNQVTIQWDA VIALYILFSW CHGGITNINC SGHIWVEPAT IFKMGMNISI YCQAAIKNCQ 70 80 90 100 110 120 PRKLHFYKNG IKERFQITRI NKTTARLWYK NFLEPHASMY CTAECPKHFQ ETLICGKDIS 130 140 150 160 170 180 SGYPPDIPDE VTCVIYEYSG NMTCTWNAGK LTYIDTKYVV HVKSLETEEE QQYLTSSYIN 190 200 210 220 230 240 ISTDSLQGGK KYLVWVQAAN ALGMEESKQL QIHLDDIVIP SAAVISRAET INATVPKTII 250 260 270 280 290 300 YWDSQTTIEK VSCEMRYKAT TNQTWNVKEF DTNFTYVQQS EFYLEPNIKY VFQVRCQETG 310 320 330 340 350 360 KRYWQPWSSL FFHKTPETVP QVTSKAFQHD TWNSGLTVAS ISTGHLTSDN RGDIGLLLGM 370 380 390 400 410 420 IVFAVMLSIL SLIGIFNRSF RTGIKRRILL LIPKWLYEDI PNMKNSNVVK MLQENSELMN 430 440 450 460 470 480 NNSSEQVLYV DPMITEIKEI FIPEHKPTDY KKENTGPLET RDYPQNSLFD NTTVVYIPDL 490 500 510 520 530 540 NTGYKPQISN FLPEGSHLSN NNEITSLTLK PPVDSLDSGN NPRLQKHPNF AFSVSSVNSL 550 560 570 580 590 600 SNTIFLGELS LILNQGECSS PDIQNSVEEE TTMLLENDSP SETIPEQTLL PDEFVSCLGI 610 620 VNEELPSINT YFPQNILESH FNRISLLEK

CATM prediction

The sequence of IL23R_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         360       370       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 DIGLLLGMIVFAVMLSILSLIGIFNRS 6.8 -55.0° 2.4 48.0 -10.0

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 359, GLY, HA1 A, 356, LEU, O 2.74Å
A, 359, GLY, HA1 B, 356, LEU, O 2.74Å