Dyslexia-associated protein KIAA0319

UniProt data

UniProt name: K0319_HUMAN (Q5VV43)

Gene name: KIAA0319

Organism: Homo sapiens (Human).

Function: Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non- cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. {ECO:0000269|PubMed:19679544}.

Subcellular location: Cell membrane {ECO:0000269|PubMed:18063668, ECO:0000269|PubMed:19419997}; Single-pass type I membrane protein {ECO:0000269|PubMed:18063668}. Early endosome membrane {ECO:0000269|PubMed:19419997}; Single-pass type I membrane protein {ECO:0000269|PubMed:18063668}. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted. {ECO:0000269|PubMed:18063668}.

Transmembrane domains:

  1. 956-976, 21 AA, Helical. {ECO:0000255}.

Sequence: 1072 AA

10 20 30 40 50 60 MAPPTGVLSS LLLLVTIAGC ARKQCSEGRT YSNAVISPNL ETTRIMRVSH TFPVVDCTAA 70 80 90 100 110 120 CCDLSSCDLA WWFEGRCYLV SCPHKENCEP KKMGPIRSYL TFVLRPVQRP AQLLDYGDMM 130 140 150 160 170 180 LNRGSPSGIW GDSPEDIRKD LTFLGKDWGL EEMSEYSDDY RELEKDLLQP SGKQEPRGSA 190 200 210 220 230 240 EYTDWGLLPG SEGAFNSSVG DSPAVPAETQ QDPELHYLNE SASTPAPKLP ERSVLLPLPT 250 260 270 280 290 300 TPSSGEVLEK EKASQLQEQS SNSSGKEVLM PSHSLPPASL ELSSVTVEKS PVLTVTPGST 310 320 330 340 350 360 EHSIPTPPTS AAPSESTPSE LPISPTTAPR TVKELTVSAG DNLIITLPDN EVELKAFVAP 370 380 390 400 410 420 APPVETTYNY EWNLISHPTD YQGEIKQGHK QTLNLSQLSV GLYVFKVTVS SENAFGEGFV 430 440 450 460 470 480 NVTVKPARRV NLPPVAVVSP QLQELTLPLT SALIDGSQST DDTEIVSYHW EEINGPFIEE 490 500 510 520 530 540 KTSVDSPVLR LSNLDPGNYS FRLTVTDSDG ATNSTTAALI VNNAVDYPPV ANAGPNHTIT 550 560 570 580 590 600 LPQNSITLNG NQSSDDHQIV LYEWSLGPGS EGKHVVMQGV QTPYLHLSAM QEGDYTFQLK 610 620 630 640 650 660 VTDSSRQQST AVVTVIVQPE NNRPPVAVAG PDKELIFPVE SATLDGSSSS DDHGIVFYHW 670 680 690 700 710 720 EHVRGPSAVE MENIDKAIAT VTGLQVGTYH FRLTVKDQQG LSSTSTLTVA VKKENNSPPR 730 740 750 760 770 780 ARAGGRHVLV LPNNSITLDG SRSTDDQRIV SYLWIRDGQS PAAGDVIDGS DHSVALQLTN 790 800 810 820 830 840 LVEGVYTFHL RVTDSQGASD TDTATVEVQP DPRKSGLVEL TLQVGVGQLT EQRKDTLVRQ 850 860 870 880 890 900 LAVLLNVLDS DIKVQKIRAH SDLSTVIVFY VQSRPPFKVL KAAEVARNLH MRLSKEKADF 910 920 930 940 950 960 LLFKVLRVDT AGCLLKCSGH GHCDPLTKRC ICSHLWMENL IQRYIWDGES NCEWSIFYVT 970 980 990 1000 1010 1020 VLAFTLIVLT GGFTWLCICC CKRQKRTKIR KKTKYTILDN MDEQERMELR PKYGIKHRST 1030 1040 1050 1060 1070 EHNSSLMVSE SEFDSDQDTI FSREKMERGN PKVSMNGSIR NGASFSYCSK DR

CATM prediction

The sequence of K0319_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         960       970       
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 EWSIFYVTVLAFTLIVLTGGFTWLCIC 6.9 -55.1° 1.5 44.7 -18.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 971, GLY, HA1 A, 968, VAL, O 2.95Å
B, 972, GLY, HA2 A, 971, GLY, O 3.43Å
A, 971, GLY, HA1 B, 968, VAL, O 2.95Å
A, 972, GLY, HA2 B, 971, GLY, O 3.43Å