VWFA and cache domain-containing protein 1

UniProt data

UniProt name: CAHD1_HUMAN (Q5VU97)

Gene name: CACHD1; Synonyms=KIAA1573, VWCD1

Organism: Homo sapiens (Human).

Function: May regulate voltage-dependent calcium channels. {ECO:0000250}.

Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 1096-1116, 21 AA, Helical. {ECO:0000255}.

Sequence: 1274 AA

10 20 30 40 50 60 MARQPEEEET AVARARRPPL WLLCLVACWL LGAGAEADFS ILDEAQVLAS QMRRLAAEEL 70 80 90 100 110 120 GVVTMQRIFN SFVYTEKISN GESEVQQLAK KIREKFNRYL DVVNRNKQVV EASYTAHLTS 130 140 150 160 170 180 PLTAIQDCCT IPPSMMEFDG NFNTNVSRTI SCDRLSTTVN SRAFNPGRDL NSVLADNLKS 190 200 210 220 230 240 NPGIKWQYFS SEEGIFTVFP AHKFRCKGSY EHRSRPIYVS TVRPQSKHIV VILDHGASVT 250 260 270 280 290 300 DTQLQIAKDA AQVILSAIDE HDKISVLTVA DTVRTCSLDQ CYKTFLSPAT SETKRKMSTF 310 320 330 340 350 360 VSSVKSSDSP TQHAVGFQKA FQLIRSTNNN TKFQANTDMV IIYLSAGITS KDSSEEDKKA 370 380 390 400 410 420 TLQVINEENS FLNNSVMILT YALMNDGVTG LKELAFLRDL AEQNSGKYGV PDRMALPVIK 430 440 450 460 470 480 GSMMVLNQLS NLETTVGRFY TNLPNRMIDE AVFSLPFSDE MGDGLIMTVS KPCYFGNLLL 490 500 510 520 530 540 GIVGVDVNLA YILEDVTYYQ DSLASYTFLI DDKGYTLMHP SLTRPYLLSE PPLHTDIIHY 550 560 570 580 590 600 ENIPKFELVR QNILSLPLGS QIIAVPVNSS LSWHINKLRE TGKEAYNVSY AWKMVQDTSF 610 620 630 640 650 660 ILCIVVIQPE IPVKQLKNLN TVPSSKLLYH RLDLLGQPSA CLHFKQLATL ESPTIMLSAG 670 680 690 700 710 720 SFSSPYEHLS QPETKRMVEH YTAYLSDNTR LIANPGLKFS VRNEVMATSH VTDEWMTQME 730 740 750 760 770 780 MSSLNTYIVR RYIATPNGVL RIYPGSLMDK AFDPTRRQWY LHAVANPGLI SLTGPYLDVG 790 800 810 820 830 840 GAGYVVTISH TIHSSSTQLS SGHTVAVMGI DFTLRYFYKV LMDLLPVCNQ DGGNKIRCFI 850 860 870 880 890 900 MEDRGYLVAH PTLIDPKGHA PVEQQHITHK EPLVANDILN HPNFVKKNLC NSFSDRTVQR 910 920 930 940 950 960 FYKFNTSLAG DLTNLVHGSH CSKYRLARIP GTNAFVGIVN ETCDSLAFCA CSMVDRLCLN 970 980 990 1000 1010 1020 CHRMEQNECE CPCECPLEVN ECTGNLTNAE NRNPSCEVHQ EPVTYTAIDP GLQDALHQCV 1030 1040 1050 1060 1070 1080 NSRCSQRLES GDCFGVLDCE WCMVDSDGKT HLDKPYCAPQ KECFGGIVGA KSPYVDDMGA 1090 1100 1110 1120 1130 1140 IGDEVITLNM IKSAPVGPVA GGIMGCIMVL VLAVYAYRHQ IHRRSHQHMS PLAAQEMSVR 1150 1160 1170 1180 1190 1200 MSNLENDRDE RDDDSHEDRG IISNTRFIAA VIERHAHSPE RRRRYWGRSG TESDHGYSTM 1210 1220 1230 1240 1250 1260 SPQEDSENPP CNNDPLSAGV DVGNHDEDLD LDTPPQTAAL LSHKFHHYRS HHPTLHHSHH 1270 LQAAVTVHTV DAEC

CATM prediction

The sequence of CAHD1_HUMAN returned 7 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
         1100      1110      
  +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 SAAVGAVAGGIMGCIMVLVLAVYAYRH 6.9 -22.9° 4.2 53.9 -27.5
Model 2 SAAVGAVAGGIMGCIMVLVLAVYAYRH 6.5 -47.1° 1.4 45.1 -21.8
Model 3 SAAVGAVAGGIMGCIMVLVLAVYAYRH 7.0 -50.1° 2.8 47.0 -20.8
Model 4 SAAVGAVAGGIMGCIMVLVLAVYAYRH 6.4 -40.9° 0.6 43.3 -19.0
Model 5 SAAVGAVAGGIMGCIMVLVLAVYAYRH 6.5 -35.3° 6.0 49.0 -18.9
Model 6 SAAVGAVAGGIMGCIMVLVLAVYAYRH 6.9 -43.0° 5.5 34.1 -18.7
Model 7 SAAVGAVAGGIMGCIMVLVLAVYAYRH 7.1 -40.0° 2.7 34.1 -12.3
Prolines* SAPVGPVAGGIMGCIMVLVLAVYAYRH          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 1098, ALA, HA A, 1097, GLY, O 2.71Å
B, 1101, GLY, HA1 A, 1098, ALA, O 3.46Å
A, 1098, ALA, HA B, 1097, GLY, O 2.71Å
A, 1101, GLY, HA1 B, 1098, ALA, O 3.46Å