UniProt data
UniProt name: VSIG8_HUMAN (Q5VU13)
Gene name: VSIG8; Synonyms=C1orf204
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.
Transmembrane domains:
- 264-284, 21 AA, Helical. {ECO:0000255}.
Sequence: 414 AA
10 20 30 40 50 60
MRVGGAFHLL LVCLSPALLS AVRINGDGQE VLYLAEGDNV RLGCPYVLDP EDYGPNGLDI
70 80 90 100 110 120
EWMQVNSDPA HHRENVFLSY QDKRINHGSL PHLQQRVRFA ASDPSQYDAS INLMNLQVSD
130 140 150 160 170 180
TATYECRVKK TTMATRKVIV TVQARPAVPM CWTEGHMTYG NDVVLKCYAS GGSQPLSYKW
190 200 210 220 230 240
AKISGHHYPY RAGSYTSQHS YHSELSYQES FHSSINQGLN NGDLVLKDIS RADDGLYQCT
250 260 270 280 290 300
VANNVGYSVC VVEVKVSDSR RIGVIIGIVL GSLLALGCLA VGIWGLVCCC CGGSGAGGAR
310 320 330 340 350 360
GAFGYGNGGG VGGGACGDLA SEIREDAVAP GCKASGRGSR VTHLLGYPTQ NVSRSLRRKY
370 380 390 400 410
APPPCGGPED VALAPCTAAA ACEAGPSPVY VKVKSAEPAD CAEGPVQCKN GLLV
CATM prediction
The sequence of VSIG8_HUMAN returned 8 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 270 280 + | + | + |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | RIGVIIGIVLGSLLALGCLAVGIWGLV | 6.5 | -33.9° | 1.6 | 57.0 | -29.0 |
| Model 2 | RIGVIIGIVLGSLLALGCLAVGIWGLV | 6.4 | -52.9° | 2.3 | 61.9 | -25.2 |
| Model 3 | RIGVIIGIVLGSLLALGCLAVGIWGLV | 7.2 | -45.1° | 0.2 | 44.5 | -23.4 |
| Model 4 | RIGVIIGIVLGSLLALGCLAVGIWGLV | 6.5 | -46.7° | 3.9 | 52.8 | -22.1 |
| Model 5 | RIGVIIGIVLGSLLALGCLAVGIWGLV | 7.0 | -55.1° | 1.5 | 44.8 | -9.9 |
| Model 6 | RIGVIIGIVLGSLLALGCLAVGIWGLV | 6.5 | -51.0° | 4.8 | 57.0 | -7.7 |
| Model 7 | RIGVIIGIVLGSLLALGCLAVGIWGLV | 7.1 | +52.3° | 1.8 | 1.2 | -2.9 |
| Model 8 | RIGVIIGIVLGSLLALGCLAVGIWGLV | 7.4 | -21.0° | 1.2 | 49.0 | -2.8 |
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 267, GLY, HA1 | A, 264, VAL, O | 2.79Å |
| B, 268, ILE, HA | A, 267, GLY, O | 2.88Å |
| A, 267, GLY, HA1 | B, 264, VAL, O | 2.79Å |
| A, 268, ILE, HA | B, 267, GLY, O | 2.88Å |
