UniProt data
UniProt name: CI135_HUMAN (Q5VTT2)
Gene name: C9orf135
Organism: Homo sapiens (Human).
Function:
Subcellular location: Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}.
Transmembrane domains:
- 124-140, 17 AA, Helical. {ECO:0000255}.
Sequence: 229 AA
10 20 30 40 50 60
MDSLDRSCQD WCDRKQHWLE IGPPDLVERK GSLTLRSHHK KYSKPVLVYS WHRDREAFPK
70 80 90 100 110 120
GYDIEGPEKV KKLCNSTYRR LGTDESPIWT SETHEKLSQM CLNTEWVEMK SKALLNEETV
130 140 150 160 170 180
SSGIIERVTG LPATGFGAVF PRHPPDWSKM CALTTYSEDY VPPYDYQPHA YPCQDDYSIV
190 200 210 220
HRKCRSQFTD LNGSKRFGIN TWHDESGIYA NSDVKQKLYP LTSGPIVPI
CATM prediction
The sequence of CI135_HUMAN returned 3 potential models
The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.
| # | Sequence and interface | d | θ | Z' | ω' | Score |
|---|---|---|---|---|---|---|
| 130 140 + | + | |
(Å) | (°) | (Å) | (°) | ||
| Model 1 | SSGIIERVTGLAATGFGAVFARH | 6.5 | -47.0° | 2.2 | 45.0 | -21.9 |
| Model 2 | SSGIIERVTGLAATGFGAVFARH | 7.3 | -50.1° | 2.8 | 47.1 | -16.9 |
| Model 3 | SSGIIERVTGLAATGFGAVFARH | 7.3 | -34.0° | 1.8 | 41.0 | -6.3 |
| Prolines* | SSGIIERVTGLPATGFGAVFPRH |
* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.
Click on the model number to visualize its details below.
MODEL 1 DETAILS
Precited structure:
Click on the image to enlarge
Download model 1 structure: PDB, PyMOL session
List of hydrogen bonds:
| Donor | Acceptor | Distance |
|---|---|---|
| B, 134, THR, HA | A, 133, ALA, O | 2.69Å |
| B, 137, GLY, HA1 | A, 134, THR, O | 2.46Å |
| B, 138, ALA, HA | A, 137, GLY, O | 3.03Å |
| A, 134, THR, HA | B, 133, ALA, O | 2.69Å |
| A, 137, GLY, HA1 | B, 134, THR, O | 2.46Å |
| A, 138, ALA, HA | B, 137, GLY, O | 3.03Å |
