Leucine-rich repeat-containing protein 38

UniProt data

UniProt name: LRC38_HUMAN (Q5VT99)

Gene name: LRRC38

Organism: Homo sapiens (Human).

Function: Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Modulates gating properties by producing a marked shift in the BK channel's voltage dependence of activation in the hyperpolarizing direction, and in the absence of calcium. {ECO:0000269|PubMed:22547800}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 250-270, 21 AA, Helical. {ECO:0000255}.

Sequence: 294 AA

10 20 30 40 50 60 MRPRAPACAA AALGLCSLLL LLAPGHACPA GCACTDPHTV DCRDRGLPSV PDPFPLDVRK 70 80 90 100 110 120 LLVAGNRIQR IPEDFFIFYG DLVYLDFRNN SLRSLEEGTF SGSAKLVFLD LSYNNLTQLG 130 140 150 160 170 180 AGAFRSAGRL VKLSLANNNL VGVHEDAFET LESLQVLELN DNNLRSLSVA ALAALPALRS 190 200 210 220 230 240 LRLDGNPWLC DCDFAHLFSW IQENASKLPK GLDEIQCSLP MESRRISLRE LSEASFSECR 250 260 270 280 290 FSLSLTDLCI IIFSGVAVSI AAIISSFFLA TVVQCLQRCA PNKDAEDEDE DKDD

CATM prediction

The sequence of LRC38_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     250       260       270 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 DLCIIIFSGVAVSIAAIISSFFLATVV 7.1 -55.2° 0.9 49.8 -9.5

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 255, GLY, HA1 A, 252, ILE, O 3.25Å
B, 256, VAL, HA A, 255, GLY, O 3.35Å
B, 259, SER, HG1 A, 256, VAL, O 2.61Å
A, 255, GLY, HA1 B, 252, ILE, O 3.25Å
A, 256, VAL, HA B, 255, GLY, O 3.35Å
A, 259, SER, HG1 B, 256, VAL, O 2.61Å