Aspartate beta-hydroxylase domain-containing protein 1

UniProt data

UniProt name: ASPH1_HUMAN (Q5U4P2)

Gene name: ASPHD1

Organism: Homo sapiens (Human).

Function:

Subcellular location: Membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.

Transmembrane domains:

  1. 73-95, 23 AA, Helical. {ECO:0000255}.

Sequence: 390 AA

10 20 30 40 50 60 MKEGRGSFSV ERGPRKERET AQSGMWKGNS PAGSQGAAME GTGGELGGQG NWGPEDAPGL 70 80 90 100 110 120 LARASLIMLP WPLPLASSAL TLLFGALTSL FLWYCYRLGS QDMQALGAGS RAGGVRGGPV 130 140 150 160 170 180 GCSEAGGPSP GGPGDPGEGP RTEGLVSRRL RAYARRYSWA GMGRVRRAAQ GGPGPGRGPG 190 200 210 220 230 240 VLGIQRPGLL FLPDLPSAPF VPRDAQRHDV ELLESSFPAI LRDFGAVSWD FSGTTPPPRG 250 260 270 280 290 300 WSPPLAPGCY QLLLYQAGRC QPSNCRRCPG AYRALRGLRS FMSANTFGNA GFSVLLPGAR 310 320 330 340 350 360 LEGRCGPTNA RVRCHLGLKI PPGCELVVGG EPQCWAEGHC LLVDDSFLHT VAHNGSPEDG 370 380 PRVVFIVDLW HPNVAGAERQ ALDFVFAPDP

CATM prediction

The sequence of ASPH1_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
  70        80        90       
|    +    |    +    |    +   		 (Å) (°) (Å) (°)  
Model 1 AWALALASSALTLLFGALTSLFLWYCYRL 7.0 -40.0° 2.7 33.7 -26.2
Model 2 AWALALASSALTLLFGALTSLFLWYCYRL 7.3 -54.9° 0.3 45.1 -19.2
Model 3 AWALALASSALTLLFGALTSLFLWYCYRL 7.2 -37.3° 2.3 35.3 -16.5
Prolines* PWPLPLASSALTLLFGALTSLFLWYCYRL          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 82, LEU, HA A, 81, THR, O 3.36Å
B, 85, GLY, HA1 A, 82, LEU, O 3.12Å
B, 86, ALA, HA A, 85, GLY, O 3.32Å
B, 89, SER, HG1 A, 86, ALA, O 2.39Å
A, 82, LEU, HA B, 81, THR, O 3.36Å
A, 85, GLY, HA1 B, 82, LEU, O 3.12Å
A, 86, ALA, HA B, 85, GLY, O 3.32Å
A, 89, SER, HG1 B, 86, ALA, O 2.39Å