MICOS complex subunit MIC10

UniProt data

UniProt name: MIC10_HUMAN (Q5TGZ0)

Gene name: MINOS1; Synonyms=C1orf151, MIC10

Organism: Homo sapiens (Human).

Function: Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. {ECO:0000269|PubMed:22114354}.

Subcellular location: Mitochondrion inner membrane {ECO:0000269|PubMed:22114354}; Single-pass membrane protein {ECO:0000269|PubMed:22114354}. Note=The C-terminus is located in the intermembrane space (By similarity), while the location of the N-terminus has not been determined yet. As some programs predict the presence of 2 closely apposed membrane domains, it has been proposed that the protein may cross the membrane twice and that both termini may face the intermembrane space (PubMed:22114354). {ECO:0000250, ECO:0000269|PubMed:22114354}.

Transmembrane domains:

  1. 17-36, 20 AA, Helical. {ECO:0000255}.

Sequence: 78 AA

10 20 30 40 50 60 MSESELGRKW DRCLADAVVK IGTGFGLGIV FSLTFFKRRM WPLAFGSGMG LGMAYSNCQH 70 DFQAPYLLHG KYVKEQEQ

CATM prediction

The sequence of MIC10_HUMAN returned 3 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
        20        30        
 +    |    +    |    +    		 (Å) (°) (Å) (°)  
Model 1 LADAVVKIGTGFGLGIVFSLTFFKRR 6.7 -41.3° -0.0 45.1 -46.8
Model 2 LADAVVKIGTGFGLGIVFSLTFFKRR 6.8 -53.0° 1.9 45.5 -20.7
Model 3 LADAVVKIGTGFGLGIVFSLTFFKRR 7.3 -54.7° 2.4 48.0 -6.9

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 21, ILE, HA A, 20, LYS, O 3.45Å
B, 24, GLY, HA1 A, 21, ILE, O 2.92Å
B, 25, PHE, HA A, 24, GLY, O 2.59Å
B, 28, GLY, HA1 A, 25, PHE, O 3.26Å
A, 21, ILE, HA B, 20, LYS, O 3.45Å
A, 24, GLY, HA1 B, 21, ILE, O 2.92Å
A, 25, PHE, HA B, 24, GLY, O 2.59Å
A, 28, GLY, HA1 B, 25, PHE, O 3.26Å