Trem-like transcript 2 protein

UniProt data

UniProt name: TRML2_HUMAN (Q5T2D2)

Gene name: TREML2; Synonyms=C6orf76, TLT2; ORFNames=UNQ6268/PRO20473

Organism: Homo sapiens (Human).

Function: Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation. {ECO:0000269|PubMed:12645956, ECO:0000269|PubMed:18650384}.

Subcellular location: Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.

Transmembrane domains:

  1. 269-289, 21 AA, Helical. {ECO:0000255}.

Sequence: 321 AA

10 20 30 40 50 60 MAPAFLLLLL LWPQGCVSGP SADSVYTKVR LLEGETLSVQ CSYKGYKNRV EGKVWCKIRK 70 80 90 100 110 120 KKCEPGFARV WVKGPRYLLQ DDAQAKVVNI TMVALKLQDS GRYWCMRNTS GILYPLMGFQ 130 140 150 160 170 180 LDVSPAPQTE RNIPFTHLDN ILKSGTVTTG QAPTSGPDAP FTTGVMVFTP GLITLPRLLA 190 200 210 220 230 240 STRPASKTGY SFTATSTTSQ GPRRTMGSQT VTASPSNARD SSAGPESIST KSGDLSTRSP 250 260 270 280 290 300 TTGLCLTSRS LLNRLPSMPS IRHQDVYSTV LGVVLTLLVL MLIMVYGFWK KRHMASYSMC 310 320 SDPSTRDPPG RPEPYVEVYL I

CATM prediction

The sequence of TRML2_HUMAN returned 1 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
      270       280       290
    |    +    |    +    |  		 (Å) (°) (Å) (°)  
Model 1 VYSTVLGVVLTLLVLMLIMVYGFWKKR 7.3 -44.9° 4.0 39.1 -8.3

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


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Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 272, GLY, HA1 A, 269, THR, O 3.40Å
B, 273, VAL, HA A, 276, THR, OG1 2.96Å
A, 272, GLY, HA1 B, 269, THR, O 3.40Å
A, 273, VAL, HA B, 276, THR, OG1 2.96Å