Mucin-21

UniProt data

UniProt name: MUC21_HUMAN (Q5SSG8)

Gene name: MUC21; Synonyms=C6orf205; ORFNames=UNQ697/PRO1342

Organism: Homo sapiens (Human).

Function:

Subcellular location: Cell membrane {ECO:0000269|PubMed:17977904}; Single-pass type I membrane protein {ECO:0000269|PubMed:17977904}; Extracellular side {ECO:0000269|PubMed:17977904}.

Transmembrane domains:

  1. 480-500, 21 AA, Helical. {ECO:0000255}.

Sequence: 566 AA

10 20 30 40 50 60 MKMQKGNVLL MFGLLLHLEA ATNSNETSTS ANTGSSVISS GASTATNSGS SVTSSGVSTA 70 80 90 100 110 120 TISGSSVTSN GVSIVTNSEF HTTSSGISTA TNSEFSTVSS GISIATNSES STTSSGASTA 130 140 150 160 170 180 TNSESSTPSS GASTATNSDS STTSSGASTA TNSDSSTTSS EASTATNSES STTSSGASTA 190 200 210 220 230 240 TNSESSTVSS RASTATNSES STTSSGASTA TNSESRTTSN GAGTATNSES STTSSGASTA 250 260 270 280 290 300 TNSESSTPSS GAGTATNSES STTSSGAGTA TNSESSTVSS GISTVTNSES STPSSGANTA 310 320 330 340 350 360 TNSESSTTSS GANTATNSDS STTSSGASTA TNSESSTTSS GASTATNSES STTSSGASTA 370 380 390 400 410 420 TNSGSSTTSS GTSTATNSES STVSSGASTA TTSESSTTSS GASTATNSES STVSSGASTA 430 440 450 460 470 480 TNSESSTTSS GANTATNSGS SVTSAGSGTA ALTGMHTTSH SASTAVSEAK PGGSLVPWEI 490 500 510 520 530 540 FLITLVSVVA AVGLFAGLFF CVRNSLSLRN TFNTAVYHPH GLNHGLGPGP GGNHGAPHRP 550 560 RWSPNWFWRR PVSSIAMEMS GRNSGP

CATM prediction

The sequence of MUC21_HUMAN returned 2 potential models

The positions at the dimer's interface are highlighted in yellow. The position at the crossing point is highlighted in orange.

# Sequence and interface d θ Z' ω' Score
     480       490       500 
   |    +    |    +    |   		 (Å) (°) (Å) (°)  
Model 1 AWEIFLITLVSVVAAVGLFAGLFFCVR 6.7 -43.1° 6.0 44.1 -26.4
Model 2 AWEIFLITLVSVVAAVGLFAGLFFCVR 6.9 -51.9° 1.4 57.2 -12.1
Prolines* PWEIFLITLVSVVAAVGLFAGLFFCVR          

* Note: this sequence contains Pro residues. CATM substituted them with Ala during the modeling. The positions are marked.

Click on the model number to visualize its details below.

MODEL 1 DETAILS

Precited structure:


Click on the image to enlarge

Download model 1 structure: PDB, PyMOL session

List of hydrogen bonds:

Donor Acceptor Distance
B, 490, ALA, HA A, 489, VAL, O 3.47Å
B, 493, GLY, HA1 A, 490, ALA, O 2.90Å
B, 494, LEU, HA A, 493, GLY, O 2.62Å
B, 497, GLY, HA1 A, 494, LEU, O 3.29Å
A, 490, ALA, HA B, 489, VAL, O 3.47Å
A, 493, GLY, HA1 B, 490, ALA, O 2.90Å
A, 494, LEU, HA B, 493, GLY, O 2.62Å
A, 497, GLY, HA1 B, 494, LEU, O 3.29Å